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Titre du document / Document title

Tumor seeding following stereotactic biopsy of brain metastases : Report of two cases

Auteur(s) / Author(s)

KARLSSON B. ; ERICSON K. ; KIHLSTRÖM L. ; GRANE P. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Departments of Neurosurgery and Neuroradiology, Karolinska Hospital, Stockholm, SUEDE

Résumé / Abstract

In a series of 22 patients treated with gamma knife surgery for brain metastasis in whom biopsy specimens were obtained via stereotactically guided procedures before the radiosurgical treatment was administered, two cases with evidence of tumor seeding were observed on subsequent follow-up examination. These findings contradict the opinion that the risk for tumor spread after a biopsy is negligible. This evidence may be explained by the fact that radiosurgery leaves the surrounding tissue unaffected by the treatment, which results in preserved anatomy around the tumor. This allows the surgeon to define the previous biopsy channel and, consequently, whether a distant tumor recurrence may have resulted from tumor seeding related to the biopsy procedure. Additionally, radiosurgical treatment leaves tumor cells that may have been spread as a result of the biopsy unaffected, giving them the potential to divide and develop into a new tumor. In contrast to this, microsurgical removal of the tumor will affect the surrounding tissue, making it impossible to detect whether new metastases are resulting from seeding. Furthermore, conventional fractionated radiation therapy will sterilize tumor cells that may have spread, thus making it impossible for these cells to regrow. The authors conclude that the risk for tumor seeding following a stereotactically guided biopsy may be higher than previously assumed.

Revue / Journal Title

Journal of neurosurgery    ISSN  0022-3085   CODEN JONSAC 

Source / Source

1997, vol. 87, no2, pp. 327-330 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Association of Neurological Surgeons, Charlottesville, VA, ETATS-UNIS  (1944) (Revue)

Mots-clés anglais / English Keywords

Metastasis

;

Brain (vertebrata)

;

Surgical biopsy

;

Stereotaxia

;

Seeding

;

Tumor

;

Radiosurgery

;

Nuclear magnetic resonance imaging

;

Complication

;

Case study

;

Male

;

Female

;

Human

;

Malignant tumor

;

Nervous system diseases

;

Central nervous system disease

;

Cerebral disorder

;

Surgery

;

Medical imagery

;

Mots-clés français / French Keywords

Métastase

;

Encéphale

;

Biopsie chirurgicale

;

Stéréotaxie

;

Ensemencement

;

Tumeur

;

Radiochirurgie

;

Imagerie RMN

;

Complication

;

Etude cas

;

Mâle

;

Femelle

;

Homme

;

Tumeur maligne

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Encéphale pathologie

;

Chirurgie

;

Imagerie médicale

;

Mots-clés espagnols / Spanish Keywords

Metástasis

;

Encéfalo

;

Biopsia quirúrgica

;

Estereotaxia

;

Siembra

;

Tumor

;

Radiocirugía

;

Imageria RMN

;

Complicación

;

Estudio caso

;

Macho

;

Hembra

;

Hombre

;

Tumor maligno

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Encéfalo patología

;

Cirugía

;

Imageneria medical

;

Localisation / Location

INIST-CNRS, Cote INIST : 6023, 35400006797477.0260

Nº notice refdoc (ud4) : 2769164



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