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Titre du document / Document title

Effect of marginal zinc deficiency on human growth and development

Auteur(s) / Author(s)

PLOYSANGAM A. (1) ; FALCIGLIA G. A. (1) ; BREHM B. J. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Nutrition Program, College of Education, University of Cincinnati, PO Box 210022, Cincinnati, OH 45221-0022, ETATS-UNIS

Résumé / Abstract

Growth and development disorders in humans caused by zinc (Zn) deficiency have been investigated for a long time. Although marginal Zn deficiency is a common nutritional problem around the world, especially in the children of developing countries where diets have less Zn available, it is difficult to identify. This review provides the progression of studies in the effect of Zn deficiency on human growth and development, and also explains the possible mechanisms of how Zn promotes these phenomena. These mechanisms involve the effects of Zn on DNA synthesis, RNA synthesis, and cell division. The concept of Zn-finger proteins explains the role of Zn in gene expression and endocrine function. Findings indicate that Zn deficiency can result in delayed growth and development which can be corrected in part by Zn supplementation.

Revue / Journal Title

Journal of tropical pediatrics    ISSN  0142-6338   CODEN JTRPAO 

Source / Source

1997, vol. 43, no4, pp. 192-198 (55 ref.)

Langue / Language

Anglais

Editeur / Publisher

Oxford University Press, Oxford, ROYAUME-UNI  (1980) (Revue)

Mots-clés anglais / English Keywords

Deficiency

;

Zinc

;

Risk factor

;

Growth defect

;

Developmental disorder

;

Bibliographic review

;

Etiopathogenesis

;

Child

;

Human

;

Metabolic diseases

;

Mots-clés français / French Keywords

Déficit

;

Zinc

;

Facteur risque

;

Défaut croissance

;

Trouble développement

;

Revue bibliographique

;

Etiopathogénie

;

Enfant

;

Homme

;

Métabolisme pathologie

;

Mots-clés espagnols / Spanish Keywords

Déficiencia

;

Zinc

;

Factor riesgo

;

Defecto crecimiento

;

Trastorno desarrollo

;

Revista bibliográfica

;

Etiopatogenia

;

Niño

;

Hombre

;

Metabolismo patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 10240, 35400006795075.0010

Nº notice refdoc (ud4) : 2759425



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