Titre du document / Document title

Aerosol electrostatics I: Properties of fine powders before and after aerosolization by dry powder inhalers

Auteur(s) / Author(s)

BYRON P. R. ⁽¹⁾ ; PEART J. ⁽¹⁾ ; STANIFORTH J. N. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Aerosol Research Group, School of Pharmacy, Box 980533, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0533, ETATS-UNIS
⁽²⁾ School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, ROYAUME-UNI

Résumé / Abstract

Purpose. To evaluate the dependence of fine particle dose charge (FPD charge) generated from powder inhalers on physico-chemical properties of the inhalation powder, inhaler type, deaggregation mechanism, dose number and/or retained powder. Methods. Electrostatic charges were determined on micronized powders and aerosolized fine particle doses withdrawn from two, high efficiency, multidose powder inhalers, Turbohaler^TM and prototype Dryhaler^TM The behavior of terbutaline sulfate, budesonide, albuterol (sulfate and base), beclomethasone dipropionate and lactose was assessed before and after aerosolization. Results. Both inhalers conferred triboelectric FPD charges during aerosolization in the range -400 pC through +200 pC. Specific charges (charge/unit mass) on the fine particle doses of budesonide from Dryhaler were significantly less than those from Turbohaler (p < 0.01). Electrostatic charges on the potentially respirable cloud of terbutaline sulfate generated by Bricanyl Turbohaler were positive and/or negative and unpredictable. With Pulmicort Turbohaler, FPD charges on budesonide were always positive. Dryhaler was used to determine the chemical dependence of fine particle triboelectrification during the aerosolization of pure materials. A triboelectric series was constructed from the Dryhaler results ranking the powders from positive to negative as budesonide > lactose > albuterol sulfate > terbutaline sulfate ≥ albuterol ≥ beclomethasone dipropionate. Conclusions. While there was no evidence of FPD charge dependence upon dose number with either inhaler, FPD charges were dependent upon the powder under investigation, as well as the construction and deaggregation mechanism of the inhaler. The specific charge on the fine particle dose of budesonide from Turbohaler corresponded to approximately 200 electronic charges per particle, a value which is known to affect both total and regional aerosol deposition in the human lung. Electrostatic charge effects may be important determinants of aerosol behavior and should not be neglected.

Revue / Journal Title

Pharmaceutical research   ISSN 0724-8741   CODEN PHREEB 

Source / Source

1997, vol. 14, n^o6, pp. 698-705 (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, New York, NY, ETATS-UNIS  (1984) (Revue)

Mots-clés anglais / English Keywords

Budesonide ; Antiinflammatory agent ; Terbutaline ; Bronchodilator ; Beclometasone dipropionate ; Salbutamol ; Electrostatic charge ; Inhaler ; Aerosol batcher ; Dosage form ; Pharmaceutical technology ; Lactose ; Fine powder ; Biological activity ; Corticosteroid ;

Mots-clés français / French Keywords

Budésonide ; Antiinflammatoire ; Terbutaline ; Bronchodilatateur ; Béclométasone dipropionate ; Salbutamol ; Charge électrostatique ; Inhalateur ; Aérosol doseur ; Forme pharmaceutique ; Technologie pharmaceutique ; Lactose ; Poudre fine ; Activité biologique ; Corticostéroïde ;

Mots-clés espagnols / Spanish Keywords

Budesónida ; Antiinflamatorio ; Terbutalina ; Broncodilatador ; Beclometasona dipropionato ; Salbutamol ; Carga electrostática ; Inhalador ; Aerosol dosificador ; Forma farmacéutica ; Tecnología farmacéutica ; Lactosa ; Polvo fino ; Actividad biológica ; Corticoesteroide ;

Localisation / Location

INIST-CNRS, Cote INIST : 20257, 35400006741483.0020