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Titre du document / Document title

Structure and function of bovine growth hormone. Bovine growth hormone as an experimental model for studies of protein-protein interactions

Auteur(s) / Author(s)

SECCHI C. (1) ; BORROMEO V. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Istituto di Fisiologia Veterinaria e Biochimica, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Via Celoria 10, 20133 Milan, ITALIE

Résumé / Abstract

Growth hormone (GH) is a polypeptide that controls the differentiation, growth and metabolism of many cell types, and is secreted from the hypophysis of all vertebrate species tested so far. Despite the overlapping evolutionary, structural, immunological and biological properties, it is well-known that GHs from distinct mammalian species have significant species-specific characteristics. The main purpose of this review is to highlight bovine GH (bGH) structural features related to its species-specific properties. Novel interest in bGH is also aroused by the advent of biotechnological methods for production of recombinant proteins. In fact recombinant bGH will have a great importance in veterinary medicine research and as a 'high tech' drug that needs to be monitored in zootechnical productions.

Revue / Journal Title

Journal of chromatography. B, Biomedical sciences and applications    ISSN  1387-2273 

Source / Source

1997, vol. 688, no2, pp. 161-177 (88 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1997-2001) (Revue)

Mots-clés anglais / English Keywords

STH

;

Bovine

;

Review

;

Molecular form

;

Aminoacid sequence

;

Homology

;

Posttranslational modification

;

Three dimensional structure

;

Antigenic determinant

;

Analysis method

;

Recombinant protein

;

Biological activity

;

Monoclonal antibody

;

Regulation(control)

;

Gene expression

;

Gene organization

;

Artiodactyla

;

Ungulata

;

Mammalia

;

Vertebrata

;

Protein hormone

;

Adenohypophyseal hormone

;

Mots-clés français / French Keywords

STH

;

Bovin

;

Article synthèse

;

Forme moléculaire

;

Séquence aminoacide

;

Homologie

;

Modification posttraductionnelle

;

Structure 3 dimensions

;

Déterminant antigénique

;

Méthode analyse

;

Protéine recombinante

;

Activité biologique

;

Anticorps monoclonal

;

Régulation

;

Expression génique

;

Organisation gène

;

Artiodactyla

;

Ungulata

;

Mammalia

;

Vertebrata

;

Hormone protéine

;

Hormone adénohypophysaire

;

Mots-clés espagnols / Spanish Keywords

STH

;

Bovino

;

Artículo síntesis

;

Forma molecular

;

Secuencia aminoácido

;

Homología

;

Modificación postraduccional

;

Estructura 3 dimensiones

;

Determinante antigénico

;

Método análisis

;

Proteína recombinante

;

Actividad biológica

;

Anticuerpo monoclonal

;

Regulación

;

Expresión genética

;

Organización gene

;

Artiodactyla

;

Ungulata

;

Mammalia

;

Vertebrata

;

Hormona proteina

;

Hormona adenohipofisaria

;

Localisation / Location

INIST-CNRS, Cote INIST : 8577 B, 35400006325618.0010

Nº notice refdoc (ud4) : 2726905



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