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Titre du document / Document title

Buprenorphine and naloxone interactions in methadone maintenance patients

Auteur(s) / Author(s)

MENDELSON J. (1) ; JONES R. T. (1) ; WELM S. (1) ; BROWN J. (1) ; BATKI S. L. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, San Francisco, California, ETATS-UNIS

Résumé / Abstract

Buprenorphine is undergoing clinical trials for the treatment of opiate addiction. Although the abuse liability of sublingual buprenorphine is low, reports of intravenous abuse have appeared. This study describes the physiologic and subjective effects of intravenously administered buprenorphine and naloxone given alone and in combination to methadone-maintained patients (40-60 mg/day). On four separate occasions at least 1 day apart, 6 subjects were administered either 0.2 mg buprenorphine, 0.1 mg naloxone, 0.2 mg buprenorphine and 0.1 mg naloxone in combination, or placebo. One male subject quit the experiment after three sessions because of excessive opiate withdrawal. Buprenorphine produced no significant physiologic or subjective effects. Naloxone produced marked opiate withdrawal symptoms. Buprenorphine in combination with naloxone produced characteristic physiologic and subjective opiate antagonist-like symptoms and signs. The parenteral abuse potential of the buprenorphine and naloxone combination is discussed.

Revue / Journal Title

Biological psychiatry    ISSN  0006-3223   CODEN BIPCBF 

Source / Source

1997, vol. 41, no11, pp. 1095-1101 (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1969) (Revue)

Mots-clés anglais / English Keywords

Buprenorphine

;

Narcotic analgesic

;

Drug of abuse

;

Naloxone

;

Narcotic antagonist

;

Drug combination

;

Intravenous administration

;

Toxicity

;

Human

;

Opiates

;

Morphinan derivatives

;

Mots-clés français / French Keywords

Buprénorphine

;

Analgésique narcotique

;

Substance toxicomanogène

;

Naloxone

;

Antagoniste analgésique narcotique

;

Association médicamenteuse

;

Voie intraveineuse

;

Toxicité

;

Homme

;

Opiacés

;

Morphinane dérivé

;

Mots-clés espagnols / Spanish Keywords

Buprenorfina

;

Analgésico narcotico

;

Sustancia toxicomanógena

;

Naloxona

;

Antagonista narcótico

;

Asociación medicamentosa

;

Vía intravenosa

;

Toxicidad

;

Hombre

;

Opiados

;

Morphinano derivado

;

Localisation / Location

INIST-CNRS, Cote INIST : 11378, 35400006561501.0030

Nº notice refdoc (ud4) : 2696979



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