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Titre du document / Document title

Lymphomas in Eμ-Pim1 transgenic mice exposed to pulsed 900 MHz electromagnetic fields

Auteur(s) / Author(s)

REPACHOLI M. H. (1) ; BASTEN A. (2) ; GEBSKI V. (3) ; NOONAN D. (4) ; FINNIE J. (5) ; HARRIS A. W. (6) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Royal Adelaide Hospital, Adelaide, AUSTRALIE
(2) Centenary Institute of Cancer Medicine & Cell Biology, Sydney University, Sydney, AUSTRALIE
(3) NHMRC Clinical Trials Centre, Sydney University, Sydney, AUSTRALIE
(4) Institute of Medical & Veterinary Science, Adelaide, AUSTRALIE
(5) Central Veterinary Laboratory, Adelaide, AUSTRALIE
(6) Walter & Eliza Hall Institute of Medical Research, Melbourne, AUSTRALIE

Résumé / Abstract

Whether radiofrequency (RF) fields are carcinogenic is controversial ; epidemiological data have been inconclusive and animal tests limited. The aim of the present study was to determine whether long-term exposure to pulse-modulated RF fields similar to those used in digital mobile telecommunications would increase the incidence of lymphoma in Ep-Piml transgenic mice, which are moderately predisposed to develop lymphoma spontaneously. One hundred female Ep-Piml mice were sham-exposed and 101 were exposed for two 30-min periods per day for up to 18 months to plane-wave fields of 900 MHz with a pulse repetition frequency of 217 Hz and a pulse width of 0.6 ms. Incident power densities were 2.6-13 W/m2 and specific absorption rates were 0.008-4.2 W/kg, averaging 0.13-1.4 W/kg. Lymphoma risk was found to be significantly higher in the exposed mice than in the controls (OR = 2.4, P = 0.006, 95% CI = 1.3-4.5). Follicular lymphomas were the major contributor to the increased tumor incidence. Thus long-term intermittent exposure to RF fields can enhance the probability that mice carrying a lymphomagenic oncogene will develop lymphomas. We suggest that such genetically cancer-prone mice provide an experimental system for more detailed assessment of dose-response relationships for risk of cancer after RF-field exposure.

Revue / Journal Title

Radiation research    ISSN  0033-7587   CODEN RAREAE 

Source / Source

1997, vol. 147, no5, pp. 631-640 (54 ref.)

Langue / Language

Anglais

Editeur / Publisher

Radiation Research Society, Lawrence, KS, ETATS-UNIS  (1954) (Revue)

Mots-clés anglais / English Keywords

Electromagnetic field

;

Experimental study

;

Animal

;

Mouse

;

Transgenic animal

;

Long term

;

Pulse modulation

;

Disease development

;

Energy density

;

Malignant lymphoma

;

Absorbed dose

;

Risk factor

;

Dose activity relation

;

Carcinogenesis

;

Histopathology

;

Rodentia

;

Mammalia

;

Vertebrata

;

Malignant hemopathy

;

Lymphoproliferative syndrome

;

Mots-clés français / French Keywords

Champ électromagnétique

;

Etude expérimentale

;

Animal

;

Souris

;

Animal transgénique

;

Long terme

;

Modulation impulsion

;

Développement maladie

;

Densité énergie

;

Lymphome malin

;

Dose absorbée

;

Facteur risque

;

Relation dose réponse

;

Carcinogenèse

;

Histopathologie

;

Rodentia

;

Mammalia

;

Vertebrata

;

Hémopathie maligne

;

Lymphoprolifératif syndrome

;

Mots-clés espagnols / Spanish Keywords

Campo electromagnético

;

Estudio experimental

;

Animal

;

Ratón

;

Animal transgénico

;

Largo plazo

;

Modulación por impulsos

;

Desarrollo enfermedad

;

Densidad energía

;

Linfoma maligno

;

Dosis absorbida

;

Factor riesgo

;

Relación dosis respuesta

;

Carcinogénesis

;

Histopatología

;

Rodentia

;

Mammalia

;

Vertebrata

;

Hemopatía maligna

;

Linfoproliferativo síndrome

;

Localisation / Location

INIST-CNRS, Cote INIST : 7792, 35400006553516.0130

Nº notice refdoc (ud4) : 2660091



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