Titre du document / Document title

ACE, angiotensinogen and obesity : a potential pathway leading to hypertension

Auteur(s) / Author(s)

COOPER R. ⁽¹⁾ ; MCFARLANE-ANDERSON N. ⁽²⁾ ; BENNETT F. I. ⁽²⁾ ; WILKS R. ⁽²⁾ ; PURAS A. ⁽¹⁾ ; TEWKSBURY D. ⁽³⁾ ; WARD R. ⁽⁴⁾ ; FORRESTER T. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL, ETATS-UNIS
⁽²⁾ Tropical Metabolism Research Unit, University of the West Indies, Mona, JAMAIQUE
⁽³⁾ Marshfield Medical Foundation, Marshfield, WI, ETATS-UNIS
⁽⁴⁾ Department of Human Genetics, University of Utah, Salt Lake City, UT, ETATS-UNIS

Résumé / Abstract

The renin-angiotensin system (RAS) plays a crucial role in the regulation of fluid volume, thereby influencing blood pressure (BP). Obesity is an important risk factor for hypertension, however the physiologic basis for this relationship has not been clarified. In a population survey we examined the potential relationship between the RAS and obesity. Based on community sampling, 449 individuals were recruited from metropolitan Kingston, Jamaica. Serum angiotensin-converting enzyme (ACE) and circulating angiotensinogen levels were measured and the associated genes were typed for previously described polymorphisms. Obese individuals (body mass index >31) had significantly higher serum ACE and angiotensinogen levels, this relationship persisted for ACE in multivariate analyses controlling for BP, hypertension status, age, and gender. The insertion/deletion polymorphism of the ACE gene was associated with variation in the levels of ACE, but inconsistently with body mass index. Variants of the angiotensinogen gene leading to amino acid substitutions at positions 174 and 235 did not influence levels either of angiotensinogen or obesity. These data suggest that obesity may alter the levels of ACE and angiotensinogen, and provide a potential pathway through which obesity leads to elevation of BP.

Revue / Journal Title

Journal of human hypertension   ISSN 0950-9240 

Source / Source

1997, vol. 11, n^o2, pp. 107-111 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Hypertension ; Obesity ; Peptidyl-dipeptidase A ; Angiotensinogen ; Serum ; Arterial pressure ; Genotype ; Risk factor ; Human ; Nutritional status ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzyme ; Cardiovascular disease ; Nutrition disorder ;

Mots-clés français / French Keywords

Hypertension artérielle ; Obésité ; Peptidyl-dipeptidase A ; Angiotensinogène ; Sérum ; Pression artérielle ; Génotype ; Facteur risque ; Homme ; Etat nutritionnel ; Angiotensin converting enzyme ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzyme ; Appareil circulatoire pathologie ; Trouble nutrition ;

Mots-clés espagnols / Spanish Keywords

Hipertensión arterial ; Obesidad ; Peptidyl-dipeptidase A ; Angiotensinógeno ; Suero ; Presión arterial ; Genotipo ; Factor riesgo ; Hombre ; Estado nutricional ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzima ; Aparato circulatorio patología ; Trastorno nutricíon ;

Localisation / Location

INIST-CNRS, Cote INIST : 22167, 35400006547419.0050