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Titre du document / Document title

Phenotypic variations and switches in HIV isolated from the blood and the gastrointestinal tissues of patients with HIV-1 infection

Auteur(s) / Author(s)

HIV/GI Research Study Group
AL-MULLA W. (1 2) ; CHURCH D. (2) ; GILL M. J. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Faculty of Medicine, Kuwait University, KOWEIT
(2) Departments of Medicine and Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Alberta, CANADA

Résumé / Abstract

The objective of this study was to determine the initial and subsequent phenotypes of HIV-1 isolated from the blood, duodenal, and colonic biopsies of 51 HIV-1 positive patients followed prospectively over 2 years. Blood and tissues were cocultured with stimulated peripheral blood monocytes, and HIV was analyzed for phenotypic expression of syncytia-induction (SI). A total of 45/51 patients had HIV-1 isolated from the blood and 35/51 had HIV isolated from gastrointestinal tract. In 12/45 patients SI-HIV-1 was isolated from the blood. In 6/12 patients the blood phenotype reverted to the NSI phenotype. SI phenotypes were also isolated from the colon and duodenum of 8/35 patients and reversion from SI to NSI virus phenotype was again observed in gut tissue of 3/8 patients. These results show that gastrointestinal tissues can harbor SI HIV phenotype. Discordant phenotypes can be found in tissue and blood of late-stage patients. Reversion of phenotypic SI expression to NSI may occur in patients receiving monotherapy as antiretroviral treatment. These results suggest that gastrointestinal tissues may act as a separate and distinct site involved in HIV replication and its associated pathogenesis.

Revue / Journal Title

Journal of medical virology    ISSN  0146-6615   CODEN JMVIDB 

Source / Source

1997, vol. 52, no1, pp. 31-34 (14 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1977) (Revue)

Mots-clés anglais / English Keywords

HIV-1 virus

;

Human

;

Cytopathology

;

Syncytium

;

Duodenum

;

Colon

;

AIDS

;

Human immunodeficiency virus

;

Lentivirinae

;

Retroviridae

;

Virus

;

Viral disease

;

Infection

;

Small intestine

;

Digestive system

;

Gut

;

Immunopathology

;

Immune deficiency

;

Mots-clés français / French Keywords

Virus HIV1

;

Homme

;

Cytopathologie

;

Syncytium

;

Duodénum

;

Côlon

;

SIDA

;

Virus immunodéficience humaine

;

Lentivirinae

;

Retroviridae

;

Virus

;

Virose

;

Infection

;

Intestin grêle

;

Appareil digestif

;

Intestin

;

Immunopathologie

;

Immunodéficit

;

Mots-clés espagnols / Spanish Keywords

HIV-1 virus

;

Hombre

;

Citopatología

;

Sincitio

;

Duodeno

;

Colón

;

SIDA

;

Human immunodeficiency virus

;

Lentivirinae

;

Retroviridae

;

Virus

;

Virosis

;

Infección

;

Intestino delgado

;

Aparato digestivo

;

Intestino

;

Inmunopatología

;

Inmunodeficiencia

;

Localisation / Location

INIST-CNRS, Cote INIST : 17422, 35400006528278.0060

Nº notice refdoc (ud4) : 2645183



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