Titre du document / Document title

Teratogenic study of doxycycline

Auteur(s) / Author(s)

CZEIZEL A. E. ⁽¹⁾ ; ROCKENBAUER M. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Human Genetics and Teratology, National Institute of Hygiene-World Health Organization Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, HONGRIE

Résumé / Abstract

Objective: To study the human teratogenic risk of doxycycline treatment during pregnancy. Methods: Paired analysis of cases with congenital abnormalities and matched healthy controls was performed in the large population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1992. Results: Of 32,804 pregnant women who had infants with no defects in the study period (control group), 63 (0.19%) were treated with doxycycline. Of 18,515 pregnant women who had offspring with congenital abnormalities, 56 (0.30%) were treated with doxycycline, a rate that is higher than that of the control group (P = .01). However, the case-control pair analysis did not show a significantly higher rate of doxycycline treatment in the second and third months of gestation in any group of congenital abnormalities. Conclusions: Treatment with doxycycline during pregnancy presents very little if any teratogenic risk to the fetus. Thus, if doxycycline treatment is necessary during pregnancy, there would appear to be no contraindication.

Revue / Journal Title

Obstetrics and gynecology   ISSN 0029-7844   CODEN OBGNAS 

Source / Source

1997, vol. 89, n^o4, pp. 524-528 (7 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, New York, NY, ETATS-UNIS  (1953) (Revue)

Mots-clés anglais / English Keywords

Doxycycline ; Chemotherapy ; Treatment ; Chorioamnionitis ; Teratogen ; Toxicity ; Malformation ; Risk factor ; Fetus ; Human ; Tetracycline derivatives ; Antibiotic ; Pregnancy disorders ; Fetal diseases ; Delivery disorders ; Placenta diseases ; Congenital disease ;

Mots-clés français / French Keywords

Doxycycline ; Chimiothérapie ; Traitement ; Chorioamnionite ; Tératogène ; Toxicité ; Malformation ; Facteur risque ; Foetus ; Homme ; Tétracycline dérivé ; Antibiotique ; Gestation pathologie ; Foetus pathologie ; Accouchement pathologie ; Placenta pathologie ; Maladie congénitale ;

Mots-clés espagnols / Spanish Keywords

Doxiciclina ; Quimioterapia ; Tratamiento ; Corioamnionitis ; Teratogeno ; Toxicidad ; Malformación ; Factor riesgo ; Feto ; Hombre ; Tetraciclina derivado ; Antibiótico ; Gestación patología ; Feto patología ; Parto patología ; Placenta patología ; Enfermedad congénita ;

Localisation / Location

INIST-CNRS, Cote INIST : 7207, 35400006444906.0070