Titre du document / Document title

Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium

Auteur(s) / Author(s)

TAN D. T. H. ⁽¹⁾ ; LIM A. S. M. ⁽¹⁾ ; GOH H.-S. ⁽²⁾ ; SMITH D. R. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Singapore National Eye Centre, Tan Tock Seng Hospital, SINGAPOUR
⁽²⁾ Molecular Biology Laboratory, Tan Tock Seng Hospital, SINGAPOUR

Résumé / Abstract

PURPOSE: To determine whether pterygium is a disorder of abnormal growth by examining the expression of the p53 gene in the conjunctiva of patients with pterygium. METHODS: Immunostaining for abnormal expression of p53 was performed using mouse monoclon-al antibody to human p53, pAb 240, on six eyes with primary pterygium and two eyes with recurrent pterygium. RESULTS: In three of the eight eyes with pterygium, specimens were positive for abnormal expression in the epithelium of the pterygium and in the superior bulbar conjunctiva. CONCLUSION: Abnormal p53 expression in the epithelium of primary and recurrent pterygium specimens suggests that pterygium is a growth disorder rather than a degeneration.

Revue / Journal Title

American journal of ophthalmology   ISSN 0002-9394   CODEN AJOPAA 

Source / Source

1997, vol. 123, n^o3, pp. 404-405 (5 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1884) (Revue)

Mots-clés anglais / English Keywords

Pterygium ; Gene expression ; Tumor suppressor gene ; Conjunctiva ; Human ; Eye disease ; Conjunctiva disease ;

Mots-clés français / French Keywords

Ptérygion ; Expression génique ; Gène suppresseur tumeur ; Conjonctive ; Homme ; Oeil pathologie ; Conjonctive pathologie ;

Mots-clés espagnols / Spanish Keywords

Pterigión ; Expresión genética ; Gen supresor tumor ; Conjuntiva ; Hombre ; Ojo patología ; Conjuntiva patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 2012, 35400006358239.0190