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Titre du document / Document title

Targeted vectors for gene therapy of cancer and retroviral infections

Auteur(s) / Author(s)

WALTHER W. (1) ; STEIN U. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13122 Berlin, ALLEMAGNE

Résumé / Abstract

Gene therapy has developed to a technology which rapidly moved from the laboratory bench to the bedside in the clinic. This implies safe, efficient and targeted gene transfer systems for suitable application to the patient. Beside the development of such gene transfer vectors of viral or nonviral origin, improvement of cell type specific and inducible gene expression is pivotal for successful gene therapy leading to targeted gene action. Numerous gene therapy approaches for treatment of cancer and retroviral infections utilize cell type specific and/or regulatable promoter and enhancer sequences for the selective expression of therapeutic genes in the desired cell populations and tissues. In this article the recent developments and the potential of expression targeting are reviewed for gene therapy approaches of cancer and retroviral infections.

Revue / Journal Title

Molecular biotechnology    ISSN  1073-6085   CODEN MLBOEO 

Source / Source

1996, vol. 6, no3, pp. 267-286 (66 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1994) (Revue)

Mots-clés anglais / English Keywords

Gene therapy

;

Review

;

Retroviridae

;

Infection

;

AIDS

;

Targeting

;

Cell population

;

Tumor

;

Virus

;

Viral disease

;

Mots-clés français / French Keywords

Thérapie génique

;

Article synthèse

;

Retroviridae

;

Infection

;

SIDA

;

Ciblage

;

Population cellulaire

;

Tumeur

;

Gène

;

Virus

;

Virose

;

Mots-clés espagnols / Spanish Keywords

Terapia génica

;

Artículo síntesis

;

Retroviridae

;

Infección

;

SIDA

;

Blancado

;

Población celular

;

Tumor

;

Virus

;

Virosis

;

Localisation / Location

INIST-CNRS, Cote INIST : 17423 B, 35400006435359.0040

Nº notice refdoc (ud4) : 2591301



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