Titre du document / Document title
Targeted vectors for gene therapy of cancer and retroviral infections
Auteur(s) / Author(s)
WALTHER W. (1) ;
STEIN U. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13122 Berlin, ALLEMAGNE
Résumé / Abstract
Gene therapy has developed to a technology which rapidly moved from the laboratory bench to the bedside in the clinic. This implies safe, efficient and targeted gene transfer systems for suitable application to the patient. Beside the development of such gene transfer vectors of viral or nonviral origin, improvement of cell type specific and inducible gene expression is pivotal for successful gene therapy leading to targeted gene action. Numerous gene therapy approaches for treatment of cancer and retroviral infections utilize cell type specific and/or regulatable promoter and enhancer sequences for the selective expression of therapeutic genes in the desired cell populations and tissues. In this article the recent developments and the potential of expression targeting are reviewed for gene therapy approaches of cancer and retroviral infections.
Revue / Journal Title
Molecular biotechnology
ISSN
1073-6085
CODEN MLBOEO
Source / Source
1996, vol. 6, n
o3, pp. 267-286 (66 ref.)
Langue / Language
Anglais
Editeur / Publisher
Springer, Heidelberg, ALLEMAGNE
(1994)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 17423 B, 35400006435359.0040
Nº notice refdoc (ud4) : 2591301
