Titre du document / Document title

Increased anti-Epstein-Barr virus antibodies in epidermotropic cutaneous T-cell lymphoma : a study of 64 patients

Auteur(s) / Author(s)

JUMBOU O. ⁽¹⁾ ; MOLLAT C. ⁽²⁾ ; N'GUYEN J. M. ⁽³⁾ ; BILLAUDEL B. ⁽²⁾ ; LITOUX P. ⁽¹⁾ ; DRENO B. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Dermatology, Hôtel Dieu, Place Alexis Ricordeau, 44035 Nantes, FRANCE
⁽²⁾ Department of Virology, Hôtel Dieu, Place Alexis Ricordeau, 44035 Nantes, FRANCE
⁽³⁾ Department of Data Processing and Statistics, CHU, Nantes, FRANCE

Résumé / Abstract

Epstein-Barr virus (EBV) is often associated with non-Hodgkin's T-cell lymphomas and has recently been found in the lesions of mycosis fungoides and Sézary syndrome. We sought to determine whether the anti-EBV antibody profile was disturbed in mycosis fungoides and Sézary syndrome and whether there are particular profiles characteristic of disease stage. Anti-EBV antibodies (anti-vCA, -EA and -EBNA) were studied in the sera of 64 patients. An immunoenzymatic technique was used, and the results were compared with the same number of age- and sex-matched healthy controls. Patients with mycosis fungoides and Sézary syndrome developed higher anti-VCA antibody titres (median 1200) than controls (median 320). Thirty-seven patients had anti-VCA ≥ 1200 vs. 19 controls (P<0.01) These elevated anti-VCA antibody titres were associated with positive EA in 19 patients versus three controls. No differences were found between the illness stages. Anti-EBV antibodies were most often found in mycosis fungoides and Sézary syndrome when the serological profile was similar to that of cellular immune deficiencies and EBV-related non-Hodgkin's lymphoma. EBV could be involved. either directly on lymphocytes or, more likely, indirectly by chronic antigenic stimulation.

Revue / Journal Title

British journal of dermatology   ISSN 0007-0963   CODEN BJDEAZ 

Source / Source

Congrès
Meeting of The British Epidermo-Epidemiology Society (BEES) N^o6, Nottingham , ROYAUME-UNI (17/01/1997)
1997, vol. 136, n^o 2, pp. 283-286 (33 ref.), pp. 212-216

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1951) (Revue)

Mots-clés anglais / English Keywords

Mycosis fungoides ; Human ; Sezary syndrome ; Skin disease ; Serology ; Epstein Barr virus ; Antibody ; Pathogenesis ; Chronic ; Gammaherpesvirinae ; Herpesviridae ; Virus ; Malignant hemopathy ; Lymphoproliferative syndrome ; Peripheral T cell lymphoma ; Non Hodgkin lymphoma ; Cutaneous hematologic disease ;

Mots-clés français / French Keywords

Mycosis fongoïde ; Homme ; Sezary syndrome ; Peau pathologie ; Sérologie ; Virus Epstein Barr ; Anticorps ; Pathogénie ; Chronique ; Gammaherpesvirinae ; Herpesviridae ; Virus ; Hémopathie maligne ; Lymphoprolifératif syndrome ; Lymphome cellule T périphérique ; Lymphome non hodgkinien ; Hématodermie ;

Mots-clés espagnols / Spanish Keywords

Micosis fungoides ; Hombre ; Sezary síndrome ; Piel patología ; Serología ; Epstein Barr virus ; Anticuerpo ; Patogenia ; Crónico ; Gammaherpesvirinae ; Herpesviridae ; Virus ; Hemopatía maligna ; Linfoproliferativo síndrome ; Linfoma célula T periférica ; Linfoma no Hodgkin ; Hematodermia ;

Localisation / Location

INIST-CNRS, Cote INIST : 1043, 35400006316567.0120