Titre du document / Document title

Anthraquinones in Rheum palmatum and Rumex dentatus (Polygonaceae), and phorbol esters in Jatropha curcas (Euphorbiaceae) with molluscicidal activity against the schistosome vector snails Oncomelania, Biomphalaria and Bulinus

Auteur(s) / Author(s)

LIU S. Y. ^{(1 2)} ; SPORER F. ⁽³⁾ ; WINK M. ⁽³⁾ ; JOURDANE J. ⁽⁴⁾ ; HENNING R. ⁽⁵⁾ ; LI Y. L. ⁽²⁾ ; RUPPEL A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Institute of Tropical Hygiene and Public Health, University, Heidelberg, ALLEMAGNE
⁽²⁾ Department of Parasitology, Tongji Medical University, Wuhan, CHINE
⁽³⁾ Institute of Pharmaceutical Biology, University, Heidelberg, ALLEMAGNE
⁽⁴⁾ Centre de Biologie et d'Ecologie Tropicale et Méditerranéenne, Université, Perpignan, FRANCE
⁽⁵⁾ Project Pourghère, CNESOLER, B.P. 134, Bamako, MALI

Résumé / Abstract

Hot water extracts of Rheum palmatum and Rheum dentatus (from China) showed molluscicidal activity against the snails Oncomelania hupensis, Biomphalaria glabrata and Bulinus globosus, which are vectors of Schistosoma japonicum, S. mansoni and S. haematobium, respectively. Activity was correlated with anthraquinones which were identified by HPLC: rhein and chrysophanol-anthron were most active (> 50% dead snails after 2 days in a 0.03 % solution). Molluscicidal activity was intermediate with Rheum-emodin and physcion and was not detectable with cinnamic acid or Aloe-emodin. The snail O. hupensis tended to be more sensitive for several compounds than B. glabrata. Extracts of Jatropha curcas seeds (from Mali) showed molluscicidal activity against both B. glabrata and O. hupensis, the latter being the more sensitive snail. The activity was associated with phorbol esters extracted from Jatropha oil. Of the pure phorbol esters tested, 4β-phorbol-13-decanoate killed both snail species at a concentration of 0.001% (10 p.p.m). As Jatropha is locally grown in Mali for other purposes, it might potentially be exploited for schistosomiasis control.

Revue / Journal Title

TM & IH. Tropical medicine & international health   ISSN 1360-2276 

Source / Source

1997, vol. 2, n^o2, pp. 179-188 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell Science, Oxford, ROYAUME-UNI  (1996) (Revue)

Mots-clés anglais / English Keywords

Anthraquinone ; Biological activity ; Biological control ; Molluscicide ; Oncomelania ; Biomphalaria ; Bulinus ; Intermediate host ; Schistosomiasis ; Polygonaceae ; Euphorbiaceae ; Gastropoda ; Mollusca ; Invertebrata ; Trematode disease ; Helminthiasis ; Parasitosis ; Infection ; Dicotyledones ; Angiospermae ; Spermatophyta ;

Mots-clés français / French Keywords

Anthraquinone ; Activité biologique ; Lutte biologique ; Molluscicide ; Oncomelania ; Biomphalaria ; Bulinus ; Hôte intermédiaire ; Schistosomiase ; Polygonaceae ; Euphorbiaceae ; rheum palmatum ; rumex dentatus ; jatropha curcas ; Gastropoda ; Mollusca ; Invertebrata ; Trématodose ; Helminthiase ; Parasitose ; Infection ; Dicotyledones ; Angiospermae ; Spermatophyta ;

Mots-clés espagnols / Spanish Keywords

Antraquinona ; Actividad biológica ; Lucha biológica ; Molusquicida ; Oncomelania ; Biomphalaria ; Bulinus ; Huesped intermediario ; Esquistosomiasis ; Polygonaceae ; Euphorbiaceae ; Gastropoda ; Mollusca ; Invertebrata ; Trematodosis ; Helmintiasis ; Parasitosis ; Infección ; Dicotyledones ; Angiospermae ; Spermatophyta ;

Localisation / Location

INIST-CNRS, Cote INIST : 26295, 35400006316047.0080