Titre du document / Document title

Study of the pharmacokinetic interaction between ethinylestradiol and amoxicillin in rabbits

Auteur(s) / Author(s)

FERNANDEZ N. ⁽¹⁾ ; SIERRA M. ⁽¹⁾ ; DIEZ M. J. ⁽¹⁾ ; TERAN T. ⁽¹⁾ ; PEREDA P. ⁽¹⁾ ; GARCIA J. J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ University of León, Department of Physiology, Pharmacology and Toxicology, Faculty of Veterinary, Campus Vegazana s/n, León, 24071, ESPAGNE

Résumé / Abstract

Several antibiotics have been implicated in oral contraception failure when they are administered at the same time as the oral contraceptive (OC) pill. In the present paper, a study about amoxicillin-ethinylestradiol (EE₂) pharmacokinetic potential interaction was studied. Two rabbit groups were utilized, the first group received amoxicillin (10 mg/kg) and EE₂ (30, 50 and 100 μg/kg, respectively), both by intravenous (i.v.) route. The second group received amoxicillin (oral route, 10 mg/kg/day) and EE₂ (i.v. route, 100 μ/kg) on day 1,4 and 8 of antibiotic treatment, respectively. After compartmental (two-compartment open model) and non-compartmental analysis of plasma concentrations, the statistical study (ANOVA p ≤ 0.05) revealed that the presence of amoxicillin did not modify the EE₂ distribution and elimination pharmacokinetic parameters (by comparison with those obtained in a previous study where EE₂ was administered alone). There also were no significant differences with the time of amoxicillin oral treatment.

Revue / Journal Title

Contraception   ISSN 0010-7824   CODEN CCPTAY 

Source / Source

1997, vol. 55, n^o1, pp. 47-52 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, New York, NY, ETATS-UNIS  (1970) (Revue)

Mots-clés anglais / English Keywords

Drug interaction ; Pharmacokinetics ; Ethinylestradiol ; Estrogen ; Amoxicillin ; Animal ; Rabbit ; Contraceptive ; Penicillin derivatives ; Lagomorpha ; Mammalia ; Vertebrata ;

Mots-clés français / French Keywords

Interaction médicamenteuse ; Pharmacocinétique ; Ethinylestradiol ; Oestrogène ; Amoxicilline ; Animal ; Lapin ; Contraceptif ; Pénicilline dérivé ; Lagomorpha ; Mammalia ; Vertebrata ;

Mots-clés espagnols / Spanish Keywords

Interacción medicamentosa ; Farmacocinética ; Etinilestradiol ; Estrógeno ; Amoxicilina ; Animal ; Conejo ; Anticonceptivo ; Penicilinas ; Lagomorpha ; Mammalia ; Vertebrata ;

Localisation / Location

INIST-CNRS, Cote INIST : 15369, 35400006231279.0090