Titre du document / Document title

Sarcoid masquerading as optic nerve sheath meningioma

Auteur(s) / Author(s)

ING E. B. ⁽¹⁾ ; GARRITY J. A. ⁽¹⁾ ; CROSS S. A. ⁽²⁾ ; EBERSOLD M. J. ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Ophthalmology, Mayo Clinic Rochester, Rochester, Minnesota, ETATS-UNIS
⁽²⁾ Department of Neurology, Mayo Clinic Rochester, Rochester, Minnesota, ETATS-UNIS
⁽³⁾ Department of Neurologic Surgery, Mayo Clinic Rochester, Rochester, Minnesota, ETATS-UNIS

Résumé / Abstract

Sarcoid manifesting as an optic nerve tumor without evidence of systemic disease is uncommon. Throughout a 2-year period, a 22-year-old white woman had progressive monocular loss of vision to the level of no light perception. Optic atrophy but no uveitis was noted in the affected eye. Magnetic resonance imaging revealed thickening and enhancement of the apical optic nerve, with tram-tracking. The presumptive diagnosis was optic nerve sheath meningioma ; however, a biopsy specimen from the optic nerve revealed sarcoid. Extensive postoperative investigations revealed no systemic sarcoidosis. To our knowledge, 17 cases similar to ours, with the diagnosis proved by optic nerve biopsy, have been previously reported in the English-language literature. Most of these were mistaken preoperatively for optic nerve sheath meningioma. None of the patients had evidence of systemic sarcoidosis on initial postoperative testing. Neuroimaging, serum level of angiotensin-converting enzyme, and clinical characteristics such as age, race, sex, and optochoroidal collaterals do not distinguish optic nerve sheath meningioma from sarcoid of the optic nerve. In the absence of uveitis or systemic involvement, optic nerve sarcoid manifesting as an orbital tumor is virtually impossible to diagnose without results of biopsy.

Revue / Journal Title

Mayo Clinic proceedings   ISSN 0025-6196   CODEN MACPAJ 

Source / Source

1997, vol. 72, n^o1, pp. 38-43 (32 ref.)

Langue / Language

Anglais

Editeur / Publisher

Mayo Medical Ventures, Rochester, MN, ETATS-UNIS  (1964) (Revue)

Mots-clés anglais / English Keywords

Meningioma ; Optic nerve ; Case study ; Differential diagnostic ; Adult ; Male ; Sarcoidosis ; Nuclear magnetic resonance imaging ; Pathology ; Human ; Nervous system diseases ; Benign neoplasm ; Systemic disease ;

Mots-clés français / French Keywords

Méningiome ; Nerf optique ; Etude cas ; Diagnostic différentiel ; Adulte ; Mâle ; Sarcoïdose ; Imagerie RMN ; Anatomopathologie ; Homme ; Système nerveux pathologie ; Tumeur bénigne ; Maladie système ;

Mots-clés espagnols / Spanish Keywords

Meningioma ; Nervio óptico ; Estudio caso ; Diagnóstico diferencial ; Adulto ; Macho ; Sarcoidosis ; Imageria RMN ; Anatomía patológica ; Hombre ; Sistema nervioso patología ; Tumor benigno ; Enfermedad sistémica ;

Localisation / Location

INIST-CNRS, Cote INIST : 3250, 35400006229315.0060