Titre du document / Document title

Non-traditional risk factors for atherosclerosis in high risk children

Auteur(s) / Author(s)

BLIEDEN L. C. ⁽¹⁾ ; KUBERGER N. ⁽¹⁾ ; GOEZ R. ⁽¹⁾ ; ABRAMOV N. ⁽²⁾ ; LARON Z. ⁽³⁾ ; WEIZMAN A. ⁽²⁾ ; GIL-AD I. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Institute of Cardiology, Schneider Children's Medical Center of Israel, Petah Tikva, ISRAEL
⁽²⁾ Psychobiology Laboratory, Felsenstein Medical Research Center, Petah Tikva, ISRAEL
⁽³⁾ Endocrine Research Unit, Schneider Children's Medical Center of Israel, Petah Tikva, ISRAEL
Sackler Faculty of Medicine, Tel Aviv University, ISRAEL

Résumé / Abstract

Non-traditional risk factors for atherosclerosis were examined in children whose fathers suffered from myocardial infarction up to age 48. Factors examined were hyperinsulinemia, insulin resistance, lipoprotein(a) [Lp(a)], fibrinogen, cardiovascular hyperreactivity, and autonomic nervous system dysfunction. Hyperinsulinemia was present in five cases (9%) and hypoinsulinemia in two. Insulin output following glucose load was significantly higher in obese children compared with controls. There was an increase in Lp(a) alone in 14 cases (24%) and with low density lipoprotein in 6 cases. Increased fibrinogen and positive correlation with insulin abnormality was present in 29% (76% females) (P >0.02). Cardiac hyperreactivity (increased systolic blood pressure) was present in 9% and increased blood pressure and pulse rate in 17%. Holter monitoring pattern was sympathetic in 39% and parasympathetic in 47% of cases. Thus a number of non-traditional risk factors were found to be higher than normal in a relatively large number of children at high risk for atherosclerosis, with 25 children having more than three risk factors.

Revue / Journal Title

Israel journal of medical sciences   ISSN 0021-2180   CODEN IJMDAI 

Source / Source

1996, vol. 32, n^o12, pp. 1255-1261 (35 ref.)

Langue / Language

Anglais

Editeur / Publisher

Israel Medical Association, Jerusalem, ISRAEL  (1965-1997) (Revue)

Mots-clés anglais / English Keywords

Atherosclerosis ; Epidemiology ; Risk factor ; Adolescent ; Public health ; Human ; Cardiovascular disease ; Vascular disease ;

Mots-clés français / French Keywords

Athérosclérose ; Epidémiologie ; Facteur risque ; Adolescent ; Santé publique ; Homme ; Appareil circulatoire pathologie ; Vaisseau sanguin pathologie ;

Mots-clés espagnols / Spanish Keywords

Ateroesclerosis ; Epidemiología ; Factor riesgo ; Adolescente ; Salud pública ; Hombre ; Aparato circulatorio patología ; Vaso sanguíneo patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 1821, 35400006226824.0260