Titre du document / Document title
Relative binding of acetaminophen, lidocaine, phenobarbital, phenytoin, quinidine, and theophylline to human tissues in vitro
Auteur(s) / Author(s)
BAILEY D. N.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Division of Laboratory Medicine, Department of Pathology, University of California Medical Center, San Diego, California 92103-8320, ETATS-UNIS
Résumé / Abstract
The relative binding of acetaminophen, lidocaine, phenobarbital, phenytoin, quinidine, and theophylline to human tissues in vitro was studied using equilibrium dialysis. Pooled human serum plus homogenates of brain, heart, liver, and placenta were incubated at 4°C with each drug at concentrations of 5 and 10 mmol/L. The percent binding of each drug to each tissue was calculated. Binding of 5% or less was considered to be negligible. By drug, the following relative binding orders were observed for those tissues demonstrating binding: acetaminophen (heart > brain, serum); lidocaine (no appreciable binding observed); phenobarbital (serum only); phenytoin (heart and liver equally; serum not studied); quinidine (serum > liver > brain, placenta); and theophylline (serum > liver). By matrix, serum bound all drugs studied except for lidocaine. Liver bound only phenytoin, quinidine, and theophylline; heart bound only acetaminophen and phenytoin; brain bound only acetaminophen and quinidine; and placenta bound only quinidine.
Revue / Journal Title
Journal of analytical toxicology
ISSN 0146-4760
CODEN JATOD3
Source / Source
1997, vol. 21, n
o1, pp. 1-4 (7 ref.)
Langue / Language
Anglais
Editeur / Publisher
Preston, Niles, IL, ETATS-UNIS
(1977)
(Revue)
Mots-clés anglais / English Keywords
Chemical analysis ;
Quantitative analysis ;
Equilibrium dialysis ;
Biological fixation ;
Biological material ;
Human ;
Tissue ;
Placenta ;
Liver ;
Brain (vertebrata) ;
Heart ;
Blood ;
Serum ;
Biological fluid ;
In vitro ;
Targeting ;
Paracetamol ;
Lidocaine ;
Phenobarbital ;
Phenytoin ;
Quinidine ;
Theophylline ;
Analgesic ;
Antipyretic ;
Hypnotic ;
Anticonvulsant ;
Antiarrhythmic agent ;
Bronchodilator ;
Mots-clés français / French Keywords
Analyse chimique ;
Analyse quantitative ;
Dialyse équilibre ;
Fixation biologique ;
Matériel biologique ;
Homme ;
Tissu ;
Placenta ;
Foie ;
Encéphale ;
Coeur ;
Sang ;
Sérum ;
Liquide biologique ;
In vitro ;
Ciblage ;
Paracétamol ;
Lidocaïne ;
Phénobarbital ;
Phénytoïne ;
Quinidine ;
Théophylline ;
Analgésique ;
Antipyrétique ;
Hypnotique ;
Anticonvulsivant ;
Antiarythmique ;
Bronchodilatateur ;
Mots-clés espagnols / Spanish Keywords
Análisis químico ;
Análisis cuantitativo ;
Diálisis equilibrio ;
Fijación biológica ;
Material biológico ;
Hombre ;
Tejido ;
Placenta ;
Hígado ;
Encéfalo ;
Corazón ;
Sangre ;
Suero ;
Líquido biológico ;
In vitro ;
Blancado ;
Paracetamol ;
Lidocaína ;
Fenobarbital ;
Fenitoína ;
Quinidina ;
Teofilina ;
Analgésico ;
Antipirético ;
Hipnótico ;
Anticonvulsivante ;
Antiarrítmico ;
Broncodilatador ;
Localisation / Location
INIST-CNRS, Cote INIST : 17415, 35400006256706.0010
Nº notice refdoc (ud4) : 2534937
