Titre du document / Document title
Indonesian medicinal plants; XVII. Characterization of quassinoids from the stems of Quassia indica
Auteur(s) / Author(s)
KITAGAWA I. (1) ;
MAHMUD T. (1) ;
YOKOTA K.-I. (1) ;
NAKAGAWA S. (1) ;
MAYUMI T. (1) ;
KOBAYASHI M. (1) ;
SHIBUYA H. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565, JAPON
(2) Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Sanzo, Gakuen-cho, Fukuyama, Hiroshima 729-02, JAPON
Résumé / Abstract
Four new quassinoids named samaderines X (1), Y (2), and Z (3), and indaquassin X (5), and a new C
19 quassinoid glycoside, 2-O-glucosylsamaderine C (10), together with five known quassinoids, samaderines B (7), C (8), and E (4), indaquassin C (6), and simarinolide (9), were isolated from the stems of Quassia indica (Simaroubaceae), an Indonesian medicinal plant. The chemical structures of these quassinoids have been elucidated on the bases of their chemical and physicochemical properties. Samaderines X (1), Z (3), E (4), and B (7) were shown to exhibit significant growth-inhibitory activity against the cultured malarial parasite Plasmodium falciparum (a chloroquine- resistant K1 strain), and 1-8 were shown to exhibit in vitro cytotoxicity (IC
50 : 0.04-1.00 μg/ml) against KB cells. Samaderines X (1), B (7), and C (8), as well as indaquassin X (5), exhibited inhibitory activity in the in vitro endothelial cell-neutrophil leukocyte adhesion assay, whereas samaderines X (1) and B (7) were found to exhibit significant anti-inflammatory activity.
Revue / Journal Title
Chemical and pharmaceutical bulletin
ISSN
0009-2363
CODEN CPBTAL
Source / Source
1996, vol. 44, n
o11, pp. 2009-2014 (14 ref.)
Langue / Language
Anglais
Editeur / Publisher
Maruzen, Tokyo, JAPON
(1958)
(Revue)
Mots-clés anglais / English Keywords
Isolation ;
Plant origin ;
Pharmacognosy ;
Medicinal plant ;
Folk medicine ;
Indonesia ;
Stem ;
Biological activity ;
In vitro ;
Antineoplastic agent ;
Cytotoxicity ;
KB cell line ;
Antimalarial ;
Parasiticid ;
Antiinflammatory agent ;
Inhibitor ;
Adhesion ;
Structural analysis ;
Oxygen heterocycle ;
Lactone ;
Enone ;
Polyol ;
Asia ;
Quassia ;
Mots-clés français / French Keywords
Isolement ;
Origine végétale ;
Pharmacognosie ;
Plante médicinale ;
Médecine traditionnelle ;
Indonésie ;
Tige ;
Activité biologique ;
In vitro ;
Anticancéreux ;
Cytotoxicité ;
Lignée KB ;
Antipaludique ;
Antiparasitaire ;
Antiinflammatoire ;
Inhibiteur ;
Adhérence ;
Analyse structurale ;
Hétérocycle oxygène ;
Lactone ;
Enone ;
Polyol ;
Quassia indica ;
Quassinoide ;
Samadérine ;
Indaquassine ;
Samadérine C(2-O-glucopyranosyl) ;
3,11c-(Epoxyméthano)phénanthro[10,1-bc]pyrane-5,10-dione dérivé ;
Asie ;
Quassia ;
Mots-clés espagnols / Spanish Keywords
Aislamiento ;
Origen vegetal ;
Farmacognosia ;
Planta medicinal ;
Medicina tradicional ;
Indonesia ;
Tallo ;
Actividad biológica ;
In vitro ;
Anticanceroso ;
Citotoxicidad ;
Célula KB ;
Antipalúdico ;
Antiparasitario ;
Antiinflamatorio ;
Inhibidor ;
Adherencia ;
Análisis estructural ;
Heterociclo oxígeno ;
Lactona ;
Enona ;
Poliol ;
Asia ;
Cuasia ;
Localisation / Location
INIST-CNRS, Cote INIST : 4123, 35400006139787.0040
Nº notice refdoc (ud4) : 2523158
