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Titre du document / Document title

Mammillary body and cerebellar shrinkage in chronic alcoholics with and without amnesia

Auteur(s) / Author(s)

SHEAR P. K. (1) ; SULLIVAN E. V. (1 2) ; LANE B. (3 4) ; PFEFFERBAUM A. (1 2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Departments of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, ETATS-UNIS
(2) Psychiatry Service, Veterans Administration Palo Alto Health Care System, Palo Alto, California, ETATS-UNIS
(3) Departments of Radiology, Stanford University School of Medicine, Stanford, California, ETATS-UNIS
(4) Radiology Service, Veterans Administration Palo Alto Health Care System, Palo Alto, California, ETATS-UNIS

Résumé / Abstract

Mammillary body and cerebellar atrophy have been described as postmortem neuropathologic markers of Korsakoff's syndrome. This study examined whether shrinkage in the mammillary bodies and cerebellum is present consistently in amnesic chronic alcoholics during life and whether the degree of abnormality in these patients differs from that in nonamnesic alcoholics and healthy controls. The severity of shrinkage in the mammillary bodies, cerebellar hemispheres, and cerebellar vermis visualizable on MRI scans was rated on a three-point scale in 33 chronic nonamnesic alcoholics, 9 amnesic alcoholics, and 20 healthy controls. Although both alcoholic groups showed significant mammillary body and cerebellar shrinkage relative to controls, the two patient groups did not differ from each other. Furthermore, four of eight amnesic patients in our sample did not demonstrate clinically significant mammillary body atrophy. These results suggest that alcoholism is associated with mammillary body and cerebellar tissue volume loss but do not provide evidence that these markers distinguish accurately between amnesic and nonamnesic patients. In addition, they suggest that visualizable mammillary body atrophy is not necessary for the development of amnesia in alcoholic patients.

Revue / Journal Title

Alcoholism, clinical and experimental research    ISSN  0145-6008   CODEN ACRSDM 

Source / Source

1996, vol. 20, no8, pp. 1489-1495 (52 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1977) (Revue)

Mots-clés anglais / English Keywords

Alcoholism

;

Human

;

Atrophia

;

Amnesia

;

Cerebellum

;

Brain (vertebrata)

;

Central nervous system

;

Pathophysiology

;

Association

;

Correlation

;

Nervous system diseases

;

Central nervous system disease

;

Cerebral disorder

;

Neurological disorder

;

Memory disorder

;

Mots-clés français / French Keywords

Alcoolisme

;

Homme

;

Atrophie

;

Amnésie

;

Cervelet

;

Encéphale

;

Système nerveux central

;

Physiopathologie

;

Association

;

Corrélation

;

Corps mammillaire

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Encéphale pathologie

;

Trouble neurologique

;

Trouble mémoire

;

Mots-clés espagnols / Spanish Keywords

Alcoholismo

;

Hombre

;

Atrofia

;

Amnesia

;

Cerebelo

;

Encéfalo

;

Sistema nervioso central

;

Fisiopatología

;

Asociación

;

Correlación

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Encéfalo patología

;

Trastorno neurológico

;

Trastorno memoria

;

Localisation / Location

INIST-CNRS, Cote INIST : 17114, 35400006075593.0250

Nº notice refdoc (ud4) : 2518509



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