Titre du document / Document title

Efficacy of silicone punctal plugs as adjuncts to topical pharmacotherapy of glaucoma-a pilot study

Auteur(s) / Author(s)

Punctal Plugs in Glaucoma Study Group
BARTLETT J. D. ^{(1 2)} ; BOAN K. ⁽¹⁾ ; CORLISS D. ⁽³⁾ ; GADDIE I. B. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Optometry, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, ETATS-UNIS
⁽²⁾ Department of Pharmacology and Toxicology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, ETATS-UNIS
⁽³⁾ Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, ETATS-UNIS

Résumé / Abstract

BACKGROUND The concept of enhancing the ocular hypotensive effects of topical antiglaucoma medications by impeding lacrimal drainage of medication has been insufficiently studied. This investigation sought to evaluate the effect of bilateral inferior punctal occlusion using silicone punctal plugs on the ocular hypotensive effect of topically applied timolol. METHODS A randomized, double-masked, cmss-over clinical trial was conducted, comparing the ocular hypotensive effect of timolol maleate 0.25 percent, both with and without occlusion of the inferior punctum with the Freeman silicone punctal plug. Following a 2-week washout of topical medication, 17 subjects with early primary open-angle glaucoma or ocular hypertension received one drop of timolol 0.25 percent in each eye with or without punctal plugs in place. Blood pressure, resting pulse rate, and intraocular pressure were measured both before timolol instillation and at intervals of 1, 2, 4, 8, and 12 hours following drop instillation. Following a 2-week washout period, the subjects were evaluated with the altemative treatment. RESULTS There was no statistically significant difference (p=0.648) in IOP levels between treatment groups. CONCLUSIONS This pilot study suggests the need for a longer-term study with larger numbers of subjects to evaluate the potential role of silicone punctal plugs to enhance the ocular bioavailability of topically applied antiglaucoma medications.

Revue / Journal Title

Journal of the American Optometric Association   ISSN 0003-0244   CODEN JAOPBD 

Source / Source

1996, vol. 67, n^o11, pp. 664-668 (11 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Optometric Association, Saint-Louis, MO, ETATS-UNIS  (1929-1999) (Revue)

Mots-clés anglais / English Keywords

Glaucoma (eye) ; Timolol ; Beta blocking agent ; Antiglaucomatous agent ; Chemotherapy ; Eye drop ; Topical administration ; Siloxane polymer ; Plug ; Combined treatment ; Human ; Eye disease ; Surgery ;

Mots-clés français / French Keywords

Glaucome ; Timolol ; Bloquant β-adrénergique ; Antiglaucomateux ; Chimiothérapie ; Collyre ; Voie externe ; Siloxane polymère ; Bouchon ; Traitement associé ; Homme ; Oeil pathologie ; Chirurgie ;

Mots-clés espagnols / Spanish Keywords

Glaucoma (ojo) ; Timolol ; Bloqueador β-adrenérgico ; Antiglaucomatoso ; Quimioterapia ; Colirio ; Vía externa ; Siloxano polímero ; Tapón ; Tratamiento asociado ; Hombre ; Ojo patología ; Cirugía ;

Localisation / Location

INIST-CNRS, Cote INIST : 18907, 35400006093570.0030