Titre du document / Document title

Use of the polymeric matrix as internal standard for quantitation of in vivo delivery of tetracycline HCI from Actisite® tetracycline fiber during periodontal treatment

Auteur(s) / Author(s)

LITCH J. M. ⁽¹⁾ ; ENCARNACION M. ⁽¹⁾ ; CHEN S. ⁽¹⁾ ; LEONARD J. ⁽¹⁾ ; BURKOTH T. L. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ ALZA Corporation, 950 Page Mill Road, PO Box 10950, Palo Alto, CA 94303-0802, ETATS-UNIS

Résumé / Abstract

Actisite® (tetracycline hydrochloride) periodontal fiber is a 23 cm monofilament containing 12.7 mg tetracycline HCl homogeneously dispersed in a polymer. This product is indicated as an adjunct to scaling and root planing to reduce pocket depth and bleeding on probing in patients with adult periodontitis. The sustained-release system, placed in the periodontal pocket for 10 d, releases the antibiotic through mechanisms of diffusion and osmosis. A study was conducted in 13 patients with moderate to severe adult periodontitis to evaluate the amount of tetracycline HCI released during therapy (based on residual drug content). Fibers placed in the pocket remained in place for an average of 9 d. Each patient had 1-4 teeth treated with fiber therapy. At the termination of therapy samples from 29 teeth were retrieved and analyzed. The amount of matrix polymer was used as an internal standard for the quantitation of tetracycline, eliminating any uncertainties with respect to recovery or contamination. An average of 31% (SD 9%) of the tetracycline HCI content was released from the fiber during the treatment period. No single fiber had less than 50% of the original drug remaining. The study demonstrated that a substantial amount of the tetracycline remains in the Actisite® fiber at removal (about 70%), which indicates that substantial drug concentrations are maintained in the pocket for the duration of treatment.

Revue / Journal Title

Journal of periodontal research   ISSN 0022-3484 

Source / Source

1996, vol. 31, n^o8, pp. 540-544 (7 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1966) (Revue)

Mots-clés anglais / English Keywords

Periodontal disease ; Tetracycline ; Kinetics ; Quantization ; In vivo ; Treatment ; Chemotherapy ; Human ; Tetracycline derivatives ; Stomatology ; Antibiotic ; Antibacterial agent ;

Mots-clés français / French Keywords

Parodontopathie ; Tétracycline ; Cinétique ; Quantification ; In vivo ; Traitement ; Chimiothérapie ; Homme ; Tétracycline dérivé ; Stomatologie ; Antibiotique ; Antibactérien ;

Mots-clés espagnols / Spanish Keywords

Parodontopatía ; Tetraciclina ; Cinética ; Cuantificación ; In vivo ; Tratamiento ; Quimioterapia ; Hombre ; Tetraciclina derivado ; Estomatología ; Antibiótico ; Antibacteriano ;

Localisation / Location

INIST-CNRS, Cote INIST : 15072, 35400006081575.0040