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Titre du document / Document title

Mirror Therapy in Lower Limb Amputees – A Look Beyond Primary Motor Cortex Reorganization = Spiegeltherapie bei Beinamputierten – mehr als Reorganisation des primär-motorischen Kortex

Auteur(s) / Author(s)

Seidel S. (1) ; Kasprian G. ; Furtner J. ; Schöpf V. ; Essmeister M. ; Sycha T. ; Auff E. ; Prayer D. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Neurology, Medical University of Vienna

Résumé / Abstract

PURPOSE: Phantom pain in upper limb amputees is associated with the extent of reorganization in the primary sensorimotor cortex. Mirror visual feedback therapy has been shown to improve phantom pain. We investigated the extent of cortical reorganization in lower limb amputees and changes in neural activity induced by mirror therapy. MATERIALS AND METHODS: Eight lower limb amputees underwent 12 sessions of MVFT and functional magnetic resonance imaging (fMRI) of the brain before the first and after the last MVFT session. FMRI sessions consisted of two runs in which subjects were instructed to perform repetitive movement of the healthy and phantom ankle. RESULTS: Before MVFT, the mean phantom pain intensity was 4.6 ± 3.1 on a visual analog scale and decreased to 1.8 ± 1.7 (p = 0.04). We did not observe a consistent pattern of cortical activation in primary sensorimotor areas during phantom limb movements. Following MVFT, increased activity was obtained in the right orbitofrontal cortex during phantom ankle movements. Comparison of cortical activity during movements of the phantom ankle and the intact ankle showed significantly higher activity in the left inferior frontal cortex (pars triangularis). CONCLUSION: These results question the known association between phantom pain and primary sensorimotor reorganization and propose reorganizational changes involving multiple cortical areas in lower limb amputees. Finally, reduction of phantom pain after mirror visual feedback therapy was associated with increased prefrontal cortical activity during phantom ankle movements.

Revue / Journal Title

RöFo. Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren    ISSN  1438-9010 

Source / Source

2011, vol. 183, no11, pp. 1051-1057 [7 page(s) (article)]

Langue / Language

Revue : Allemand

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1999) (Revue)

Mots-clés d'auteur / Author Keywords

MR functional imaging


neural networks




Localisation / Location


© Georg Thieme Verlag KG Stuttgart · New York
Nº notice refdoc (ud4) : 24577007

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