RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Review: The neurobiology of varicella zoster virus infection

Auteur(s) / Author(s)

GILDEN D. (1 2) ; MAHALINGAM R. (1) ; NAGEL M. A. (1) ; PUGAZHENTHI S. (3 4) ; COHRS R. J. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Neurology, University of Colorado School of Medicine, Aurora, ETATS-UNIS
(2) Department of Microbiology, University of Colorado School of Medicine, Aurora, ETATS-UNIS
(3) Department of Medicine, University of Colorado School of Medicine, Aurora, ETATS-UNIS
(4) Denver VA Medical Center, Denver, ETATS-UNIS

Résumé / Abstract

Varicella zoster virus (VZV) is a neurotropic herpesvirus that infects nearly all humans. Primary infection usually causes chickenpox (varicella), after which virus becomes latent in cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis. Although VZV cannot be isolated from human ganglia, nucleic acid hybridization and, later, polymerase chain reaction proved that VZV is latent in ganglia. Declining VZV-specific host immunity decades after primary infection allows virus to reactivate spontaneously, resulting in shingles (zoster) characterized by pain and rash restricted to one to three dermatomes. Multiple other serious neurological and ocular disorders also result from VZV reactivation. This review summarizes the current state of knowledge of the clinical and pathological complications of neurological and ocular disease produced by VZV reactivation, molecular aspects of VZV latency, VZV virology and VZV-specific immunity, the role of apoptosis in VZV-induced cell death and the development of an animal model provided by simian varicella virus infection of monkeys.

Revue / Journal Title

Neuropathology and applied neurobiology    ISSN  0305-1846   CODEN NANEDL 

Source / Source

2011, vol. 37, no5, pp. 441-463 [23 page(s) (article)] (202 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1975) (Revue)

Mots-clés anglais / English Keywords

Skin disease

;

Infection

;

Viral disease

;

Apoptosis

;

Animal model

;

Review

;

Nervous system diseases

;

Varicella

;

Mots-clés français / French Keywords

Pathologie de la peau

;

Infection

;

Virose

;

Apoptose

;

Modèle animal

;

Article synthèse

;

Pathologie du système nerveux

;

Varicelle

;

Mots-clés espagnols / Spanish Keywords

Piel patología

;

Infección

;

Virosis

;

Apoptosis

;

Modelo animal

;

Artículo síntesis

;

Sistema nervioso patología

;

Varicela

;

Mots-clés d'auteur / Author Keywords

animal model

;

apoptosis

;

latency

;

neurological disease

;

VZV

;

Localisation / Location

INIST-CNRS, Cote INIST : 17534, 35400019049486.0010

Nº notice refdoc (ud4) : 24320890



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas