Titre du document / Document title

Rectal misoprostol in the prevention of postpartum hemorrhage : A placebo-controlled trial

Auteur(s) / Author(s)

BAMIGBOYE A. A. ^{(1 2)} ; HOFMEYR G. J. ^{(1 2)} ; MERRELL D. A. ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Obstetrics and Gynaecology, Coronation Hospital, AFRIQUE DU SUD
⁽²⁾ University of the Witwatersrand, AFRIQUE DU SUD
⁽³⁾ Department of Obstetrics and Gynaecology, Natalspruit Hospital, AFRIQUE DU SUD

Résumé / Abstract

OBJECTIVE: This study investigated the effectiveness of rectal misoprostol in preventing postpartum hemorrhage. STUDY DESIGN: In a randomized, placebo-controlled study, 550 women were randomly allocated to rectally receive 400 μg misoprostol or nonidentical placebo after normal vaginal delivery. Any excessive bleeding was actively managed with conventional oxytocic agents. Blood loss was measured directly. RESULTS: The baseline variables were similar. Blood loss of ≥1000 mL occurred in 4.8% (13/270) of the misoprostol group and 7% (19/272) of the placebo group. Additional oxytocic therapy was required by 3.3% and 4.7%, respectively. No predominance of side effects, particularly shivering, was noted in the misoprostol group. CONCLUSIONS: Postpartum use of 400 μg rectal misoprostol was well tolerated and associated with a statistically nonsignificant trend toward less postpartum hemorrhage. The early active management of excessive bleeding with conventional oxytocic agents may have reduced the potential of the study to detect differences between the groups.

Revue / Journal Title

American journal of obstetrics and gynecology   ISSN 0002-9378   CODEN AJOGAH 

Source / Source

Congrès
Annual Meeting of the Society of Perinatal Obstetricians N^o18, Miami Beach, Florida , ETATS-UNIS (02/02/1998)
1998, vol. 179, n^o 4, pp. 841-998 (24 ref.), pp. 1043-1046

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Philadelphia, PA, ETATS-UNIS  (1920) (Revue)

Mots-clés anglais / English Keywords

Misoprostol ; Rectal administration ; Chemotherapy ; Hemorrhage ; Puerperium ; Prevention ; Controlled therapeutic trial ; Randomization ; Human ; Female ; Prostaglandin derivatives ; Puerperal disorders ; Cardiovascular disease ; Vascular disease ;

Mots-clés français / French Keywords

Misoprostol ; Voie rectale ; Chimiothérapie ; Hémorragie ; Postpartum ; Prévention ; Essai thérapeutique contrôlé ; Randomisation ; Homme ; Femelle ; Prostaglandine dérivé ; Postpartum pathologie ; Appareil circulatoire pathologie ; Vaisseau sanguin pathologie ;

Mots-clés espagnols / Spanish Keywords

Misoprostol ; Vía rectal ; Quimioterapia ; Hemorragia ; Postparto ; Prevención ; Ensayo terapéutico controlado ; Aleatorización ; Hombre ; Hembra ; Prostaglandina derivado ; Postparto patología ; Aparato circulatorio patología ; Vaso sanguíneo patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 3053, 35400007134985.0400