Titre du document / Document title

A further examination of the time-dependent effects of oxazepam and lorazepam on implicit and explicit memory

Auteur(s) / Author(s)

BUFFETT-JERROTT S. E. ⁽¹⁾ ; STEWART S. H. ⁽¹⁾ ; TEEHAN M. D. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Psychology, Dalhousie University, Life Sciences Centre, 1355 Oxford Street, Halifax, Nova Scotia, B3H 4J1, CANADA
⁽²⁾ Department of Psychiatry, Dalhousie University, Life Sciences Centre, 1355 Oxford Street, Halifax, Nova Scotia, B3H 4J1, CANADA

Résumé / Abstract

Until recently, research indicated that all benzodiazepines impair explicit memory, while only lorazepam impairs priming. Stewart and associates provided preliminary data which indicated that both oxazepam and lorazepam may impair implicit memory, but in a time-dependent fashion. The present study was designed to replicate Stewart et al.'s findings after overcoming several limitations of the original study. Thirty subjects were administered an acute dose of lorazepam (2 mg), oxazepam (30 mg) or a placebo and were tested with an implicit (word-stem completion) test and an explicit (cued recall) test. However, subjects were only tested at 170 min post-drug (close to oxazepam's theoretical peak concentration) to rule out the possible explicit memory contamination explanation of the Stewart et al. implicit memory findings. Consistent with previous research, both drugs impaired explicit memory relative to placebo. Also, both lorazepam and oxazepam impaired priming performance, supporting the time-dependence' interpretation of the Stewart et al. findings. The results also indicate that episodic memory is impaired by both benzodiazepines in a time-dependent fashion even when the research methodology used involves everyday memory demands.

Revue / Journal Title

Psychopharmacologia   ISSN 0033-3158   CODEN PSYPAG 

Source / Source

1998, vol. 138, n^o 3-4 (159 p.)  (44 ref.), pp. 344-353

Langue / Language

Anglais

Editeur / Publisher

Springer, Berlin, ALLEMAGNE  (1959) (Revue)

Mots-clés anglais / English Keywords

Oxazepam ; Lorazepam ; Psychotropic ; Tranquillizer ; Anticonvulsant ; Memory disorder ; Explicit memory ; Implicit memory ; Acquisition process ; Human ; Normal ; Time study ; Time response relation ; Benzodiazepine derivatives ; Toxicity ; Oral administration ; Cognitive disorder ;

Mots-clés français / French Keywords

Oxazépam ; Lorazépam ; Psychotrope ; Tranquillisant ; Anticonvulsivant ; Trouble mémoire ; Mémoire explicite ; Mémoire implicite ; Processus acquisition ; Homme ; Normal ; Etude temps ; Relation temps réponse ; Benzodiazépine dérivé ; Toxicité ; Voie orale ; Trouble cognition ;

Mots-clés espagnols / Spanish Keywords

Oxazepam ; Lorazepam ; Psicotropo ; Tranquilizante ; Anticonvulsivante ; Trastorno memoria ; Memoria explícita ; Memoria implícita ; Proceso adquisición ; Hombre ; Normal ; Estudio tiempo ; Relación tiempo respuesta ; Benzodiazepina derivado ; Toxicidad ; Vía oral ; Trastorno cognitivo ;

Localisation / Location

INIST-CNRS, Cote INIST : 1761, 35400007265169.0130