Titre du document / Document title
Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis
Auteur(s) / Author(s)
NOREEN Y. (1) ;
SERRANO G. (1) ;
PERERA P. (1) ;
BOHLIN L. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Division of Pharmacognosy, Department of Pharmacy, Biomedical Centre, Uppsala University, Uppsala, SUEDE
Résumé / Abstract
Extracts from the four plant species Atuna racemosa Raf. ssp. racemosa, Syzygium corynocarpum (A. Gray) C. Muell., Syzygium malaccense (L.) Merr. & Perry and Vantanea peruviana Macbr., traditionally used for inflammatory conditions, were fractionated using a cyclooxygenase-1 catalysed prostaglandin biosynthesis in vitro assay. The flavan-3-ol derivatives (+)-catechin, ( +)-gallocatechin, 4'-O-Me-ent-gallocatechin, ouratea-catechin and ouratea-proanthocynidin A were isolated as active principles. The IC
50 values ranged from 3.3 μM to 138 μM whilst indomethacin under the same test conditions had an IC
50 value of 1.1 μM. The flavonol rhamnosides mearnsitrin, myricitrin and quercitrin were also isolated. When further tested for inhibitory effect on cyclooxygenase-2 catalysed prostaglandin biosynthesis, the five flavan-3-ol derivatives exhibited from equal to weaker inhibitory potencies, as compared to their cyclooxygenase-1 inhibitory effects. The flavonol rhamnosides were inactive towards both enzymes.
Revue / Journal Title
Planta medica
ISSN
0032-0943
CODEN PLMEAA
Source / Source
1998, vol. 64, n
o6, pp. 520-524 (30 ref.)
Langue / Language
Anglais
Editeur / Publisher
Thieme, Stuttgart, ALLEMAGNE
(1953)
(Revue)
Mots-clés anglais / English Keywords
Plant origin ;
Polyphenol ;
Flavonoid ;
Extract ;
Isolation ;
Biological activity ;
Enzyme inhibitor ;
Prostaglandin-endoperoxide synthase ;
Medicinal plant ;
In vitro ;
Pharmacognosy ;
Oxidoreductases ;
Enzyme ;
Chrysobalanaceae ;
Dicotyledones ;
Angiospermae ;
Spermatophyta ;
Myrtaceae ;
Mots-clés français / French Keywords
Origine végétale ;
Polyphénol ;
Flavonoïde ;
Extrait ;
Isolement ;
Activité biologique ;
Inhibiteur enzyme ;
Prostaglandin-endoperoxide synthase ;
Plante médicinale ;
In vitro ;
Pharmacognosie ;
Atuna racemosa ;
Syzygium corynocarpum ;
Syzygium malaccense ;
Vantanea peruviana ;
Cyclooxygenase COX-1 ;
Cyclooxygenase COX-2 ;
Oxidoreductases ;
Enzyme ;
Chrysobalanaceae ;
Dicotyledones ;
Angiospermae ;
Spermatophyta ;
Myrtaceae ;
Mots-clés espagnols / Spanish Keywords
Origen vegetal ;
Polifenol ;
Flavonoide ;
Extracto ;
Aislamiento ;
Actividad biológica ;
Inhibidor enzima ;
Prostaglandin-endoperoxide synthase ;
Planta medicinal ;
In vitro ;
Farmacognosia ;
Oxidoreductases ;
Enzima ;
Chrysobalanaceae ;
Dicotyledones ;
Angiospermae ;
Spermatophyta ;
Myrtaceae ;
Localisation / Location
INIST-CNRS, Cote INIST : 9624, 35400007283972.0070
Nº notice refdoc (ud4) : 2410859
