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Titre du document / Document title

Genotoxic properties of 2-dodecylcyclobutanone, a compound formed on irradiation of food containing fat

Auteur(s) / Author(s)

DELINCEE H. (1) ; POOL-ZOBEL B.-L. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Engesserstr. 20, 76131 Karlsruhe, ALLEMAGNE

Résumé / Abstract

When food containing fat is treated by ionizing radiation, a group of 2-alkylcyclobutanones is formed. These components contain the same number of carbon atoms as their precursor fatty acids and the alkyl group is located in ring position 2. Thus, from palmitic acid 2-dodecylcyclobutanone is derived. To date, there is no evidence that the cyclobutanones occur in unirradiated food. Therefore, these components cannot be considered inherent to food, and for questions pertaining to risk assessment of irradiated food it would be advisable to determine the genotoxic and toxic potentials of cyclobutanones. Measurements of DNA damage in cells exposed to 2-dodecylcyclobutanone, employing the single cell microgel electrophoresis technique, have been carried out. In vitro experiments using rat and human colon cells indicate that 2-dodecylcyclobutanone in the concentration range of about 0.30 - 1.25 mg/ml induces DNA strand breaks in the cells. Simultaneously, a concentration related cytotoxic effect is observed as was determined by trypan blue exclusion. To which extent these in vitro findings are of relevancy for the in vivo human exposure situation needs to be investigated in further studies. In vivo tests in rats are in progress.

Revue / Journal Title

Radiation physics and chemistry    ISSN  0969-806X 

Source / Source

Congrès
IMRP-10 International Meeting on Radiation Processing No10, Anaheim, California , ETATS-UNIS (11/05/1997)
1998, vol. 52, no 1-6 (679 p.)  (11 ref.), [Notes: Selected papers], pp. 39-42

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1993) (Revue)

Mots-clés anglais / English Keywords

In vitro

;

Human

;

Edible fat

;

Gamma irradiation

;

Irradiated product

;

Reaction product

;

Cytotoxicity test

;

Mutagenicity testing

;

Rat

;

Ionizing irradiation

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés français / French Keywords

In vitro

;

Homme

;

Corps gras alimentaire

;

Irradiation gamma

;

Produit irradié

;

Produit réaction

;

Test cytotoxicité

;

Test mutagénicité

;

Rat

;

Cyclobutanone

;

Irradiation ionisante

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés espagnols / Spanish Keywords

In vitro

;

Hombre

;

Grasa alimentaria

;

Irradiación gama

;

Producto irradiado

;

Producto reacción

;

Prueba citotoxicidad

;

Prueba mutagenicidad

;

Rata

;

Irradiación ionizante

;

Rodentia

;

Mammalia

;

Vertebrata

;

Localisation / Location

INIST-CNRS, Cote INIST : 14649, 35400007226484.0070

Nº notice refdoc (ud4) : 2390458



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