Titre du document / Document title
Genotoxic properties of 2-dodecylcyclobutanone, a compound formed on irradiation of food containing fat
Auteur(s) / Author(s)
DELINCEE H. (1) ;
POOL-ZOBEL B.-L. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Engesserstr. 20, 76131 Karlsruhe, ALLEMAGNE
Résumé / Abstract
When food containing fat is treated by ionizing radiation, a group of 2-alkylcyclobutanones is formed. These components contain the same number of carbon atoms as their precursor fatty acids and the alkyl group is located in ring position 2. Thus, from palmitic acid 2-dodecylcyclobutanone is derived. To date, there is no evidence that the cyclobutanones occur in unirradiated food. Therefore, these components cannot be considered inherent to food, and for questions pertaining to risk assessment of irradiated food it would be advisable to determine the genotoxic and toxic potentials of cyclobutanones. Measurements of DNA damage in cells exposed to 2-dodecylcyclobutanone, employing the single cell microgel electrophoresis technique, have been carried out. In vitro experiments using rat and human colon cells indicate that 2-dodecylcyclobutanone in the concentration range of about 0.30 - 1.25 mg/ml induces DNA strand breaks in the cells. Simultaneously, a concentration related cytotoxic effect is observed as was determined by trypan blue exclusion. To which extent these in vitro findings are of relevancy for the in vivo human exposure situation needs to be investigated in further studies. In vivo tests in rats are in progress.
Revue / Journal Title
Radiation physics and chemistry
ISSN
0969-806X
Source / Source
Congrès
IMRP-10 International Meeting on Radiation Processing N
o10, Anaheim, California
, ETATS-UNIS
(11/05/1997)
1998, vol. 52, n
o 1-6 (679 p.) (11 ref.), [Notes: Selected papers], pp. 39-42
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Kidlington, ROYAUME-UNI
(1993)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 14649, 35400007226484.0070
Nº notice refdoc (ud4) : 2390458
