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Titre du document / Document title

Comparison of outcomes based on treatment algorithms for rhabdomyosarcoma of the bladder/prostate: combined results from the Children's Oncology Group, German Cooperative Soft Tissue Sarcoma Study, Italian Cooperative Group, and International Society of Pediatric Oncology Malignant Mesenchymal Tumors Committee

Auteur(s) / Author(s)

RODEBERG David A. (1) ; ANDERSON James R. (2) ; ARNDT Carola A. (3) ; FERRER Fernando A. (4) ; BEVERLY RANEY Richard (5) ; JENNEY Meriel E. (6) ; BRECH Ines B. (7) ; KOSCIELNIAK Ewa (7) ; CARLI Modesto (8) ; BISOGNO Gianni (8) ; OBERLIN Odile (9 10) ; REY Annie (9 10) ; ULTRICH Fred (2) ; STEVENS Michael C. G. (11) ; MEYER William H. (12) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, ETATS-UNIS
(2) Department of Preventive and Societal Medicine, University of Nebraska Medical Center, Omaha, NE, ETATS-UNIS
(3) Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, ETATS-UNIS
(4) Division of Pediatric Urology, University of Connecticut Health Center, Farmington, CT, ETATS-UNIS
(5) Division of Pediatrics, Children's Cancer Center, University of Texas M. D. Anderson Cancer Center, Houston, TX, ETATS-UNIS
(6) University of Wales and Llandough Hospital, National Health Service Trust, Penarth, South Glamorgan, ROYAUME-UNI
(7) Pediatric 5 (Oncology, Hematology, Immunology), Olga Hospital, Klinikum Stuttgart, ALLEMAGNE
(8) Department of Pediatrics, Division of Hematology/Oncology, University Hospital of Padova, Padova, ITALIE
(9) Department of Pediatrics, Institut Gustave Roussy, Villejuif, FRANCE
(10) Department of Biostatistics, Institut Gustave Roussy, Villejuif, FRANCE
(11) Institute of Child Life and Health, University of Bristol, Bristol, ROYAUME-UNI
(12) Department of Pediatric Hematology/Oncology, University of Oklahoma Health Science Center, Oklahoma City, OK, ETATS-UNIS

Résumé / Abstract

The purpose of this study was to determine patient characteristics and outcomes for bladder/prostate (BP) rhabdomyosarcoma (RMS) using an international cohort of prospectively treated patients comparing different treatment algorithms. Data were collected from 379 patients (1979-1998) treated on protocol; Intergroup Rhabdomyosarcoma Study, IRS-IV (n = 239 patients), International Society of Pediatric Oncology Malignant Mesenchymal Tumors (MMT) Committee MMT-84 and -89 (n = 74), Italian Cooperative Group, RMS-79 and RMS-88 Studies (n = 37) or German Cooperative Soft Tissue Sarcoma Study CWS-91 protocols (n = 29). A total of 322 (85%) patients had localized embryonal RMS (ERMS) and 27 had metastatic disease. Thirty patients (21 local disease; 9 metastatic) had nonembryonal BP RMS. Patients with localized ERMS had large tumors (64% >5 cm) that were invasive (54%) with uninvolved regional lymph nodes (NO, 93%). The 5-year failure-free survival (FFS) was 75% and the overall survival (OS) was 84%, with 89% of deaths attributed to disease. Treatment failures were usually local disease recurrence (60%). Predictors of FFS included T-stage (invasiveness), size, and histology. FFS was decreased for patients not receiving initial radiotherapy but this did not translate into a decreased OS. The 21 patients with localized nonembryonal BP RMS had a FFS and OS of 47%. The 36 patients with metastatic disease were more likely to be older and had large tumors that were invasive with alveolar histology and regional lymph node involvement. The 5-year FFS and OS were 41 and 44%, respectively. In conclusion, the majority of BP RMS patients had localized ERMS with a resultant good prognosis using current treatment algorithms. There were differences in FFS between treatment protocols but this did not result in an altered OS.

Revue / Journal Title

International journal of cancer    ISSN  0020-7136   CODEN IJCNAW 

Source / Source

2011, vol. 128, no5, pp. 1232-1239 [8 page(s) (article)] (48 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Blackwell, Hoboken, NJ, ETATS-UNIS  (1966) (Revue)

Mots-clés anglais / English Keywords

Urogenital system

;

Urinary system

;

Striated muscle disease

;

Europe

;

Human

;

Cancer

;

Mesenchymal cell

;

Pediatrics

;

International

;

Italy

;

Germany

;

Cancerology

;

Child

;

Prostate

;

Urinary bladder

;

Malignant tumor

;

Algorithm

;

Treatment

;

Soft tissue sarcoma

;

Prognosis

;

Comparative study

;

Rhabdomyosarcoma

;

Mots-clés français / French Keywords

Appareil urogénital

;

Appareil urinaire

;

Pathologie du muscle strié

;

Europe

;

Homme

;

Cancer

;

Cellule mésenchymateuse

;

Pédiatrie

;

International

;

Italie

;

Allemagne

;

Cancérologie

;

Enfant

;

Prostate

;

Vessie urinaire

;

Tumeur maligne

;

Algorithme

;

Traitement

;

Sarcome des tissus mous

;

Pronostic

;

Etude comparative

;

Rhabdomyosarcome

;

Mots-clés espagnols / Spanish Keywords

Aparato urogenital

;

Aparato urinario

;

Músculo estriado patología

;

Europa

;

Hombre

;

Cáncer

;

Célula mesenquimatosa

;

Pediatría

;

Internacional

;

Italia

;

Alemania

;

Cancerología

;

Niño

;

Prostata

;

Vejiga

;

Tumor maligno

;

Algoritmo

;

Tratamiento

;

Sarcoma de tejidos blandos

;

Pronóstico

;

Estudio comparativo

;

Rabdomiosarcoma

;

Mots-clés d'auteur / Author Keywords

pediatric

;

rhabdomyosarcoma

;

bladder

;

prostate

;

outcomes

;

Localisation / Location

INIST-CNRS, Cote INIST : 13027, 35400019188243.0230

Nº notice refdoc (ud4) : 23756111



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