Titre du document / Document title
The use of combined intravenous pulse methylprednisolone and oral cyclosporin A in the treatment of corneal graft rejection : A preliminary study
Auteur(s) / Author(s)
LAM D. S. C.
(1) ;
WONG A. K. K.
(1) ;
THAM C. C. Y.
(1) ;
LEUNG A. T. S.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T, HONG-KONG
Résumé / Abstract
Purpose Oral cyclosporin A used in addition to high-dose intravenous pulse methylprednisolone has been shown to have an adjunctive effect in reversing the rejection of liver and renal transplants. The aim of this prospective study was to evaluate the benefits and risks of this combined drug therapy in acute corneal graft rejection. Methods Eleven patients with acute corneal graft rejection received the combined regimen of a single pulse of intravenous methylprednisolone (500 mg) and a low dose of oral cyclosporin A (to maintain a trough blood level of 100-200 μg/l). Results At a mean follow-up of 16.5 months (range 8-22 months) from the presentation of the graft rejection, reversal of graft rejection was achieved in 10 of 11 cases (90.9%). No recurrence of graft rejection was encountered during the study period. One patient developed a duodenal ulcer, which healed after medical treatment. No other complications were encountered. Conclusions The high efficacy and low risk of the combined regimen demonstrated in this preliminary study call for a larger-scale prospective double-masked study to confirm the value of this treatment protocol.
Revue / Journal Title
Eye
ISSN 0950-222X
CODEN EYEEEC
Source / Source
1998, vol. 12 (4), pp. 615-618 (29 ref.)
Langue / Language
Anglais
Editeur / Publisher
Nature Publishing Group, Basingstoke, ROYAUME-UNI
(1987)
(Revue)
Mots-clés anglais / English Keywords
Homograft ;
Cornea ;
Rejection ;
Graft(material) ;
Ciclosporin ;
Immunosuppressive agent ;
Oral administration ;
Methylprednisolone ;
High dose ;
Intravenous administration ;
Drug combination ;
Chemotherapy ;
Treatment ;
Human ;
Corticosteroid ;
Graft ;
Surgery ;
Mots-clés français / French Keywords
Homogreffe ;
Cornée ;
Rejet ;
Greffon ;
Ciclosporine ;
Immunodépresseur ;
Voie orale ;
Méthylprednisolone ;
Dose forte ;
Voie intraveineuse ;
Association médicamenteuse ;
Chimiothérapie ;
Traitement ;
Homme ;
Corticostéroïde ;
Greffe ;
Chirurgie ;
Mots-clés espagnols / Spanish Keywords
Homoinjerto ;
Córnea ;
Rechazo ;
Injerto(material) ;
Ciclosporina ;
Inmunodepresor ;
Vía oral ;
Metilprednisolona ;
Dosis fuerte ;
Vía intravenosa ;
Asociación medicamentosa ;
Quimioterapia ;
Tratamiento ;
Hombre ;
Corticoesteroide ;
Injerto ;
Cirugía ;
Localisation / Location
INIST-CNRS, Cote INIST : 21076, 35400007018774.0010
Nº notice refdoc (ud4) : 2355547
