Titre du document / Document title

Characterization of β-phenylethylamine-induced monoamine release in rat nucleus accumbens : a microdialysis study

Auteur(s) / Author(s)

NAKAMURA M. ⁽¹⁾ ; ISHII A. ⁽²⁾ ; NAKAHARA D. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Psychology, Hamamatsu University School of Medicine, 3600 Honda-cho, Hamamatsu 431-3192, JAPON
⁽²⁾ Department of Legal Medicine, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, JAPON

Résumé / Abstract

In vivo microdialysis was used to investigate the effect of β-phenylethylamine on extracellular levels of monoamines and their metabolites in the nucleus accumbens of conscious rats. At all doses tested (1, 10 and 100 μM), infusion of β-phenylethylamine through the microdialysis probe significantly increased extracellular levels of dopamine in the nucleus accumbens. These increases were dose-related. The increase in dopamine levels induced by 100 μM β-phenylethylamine was not affected by co-perfusion of 4 μM tetrodotoxin. The ability of 100 μM β-phenylethylamine to increase the extracellular level of dopamine was comparable to that of the same dose of methamphetamine. On the other hand, β-phenylethylamine had a much less potent enhancing effect on 5-hydroxytryptamine (5-HT) than dopamine levels. Only the highest dose (100 μM) caused a statistically significant effect on 5-HT levels. Over the dose range tested (1, 10 and 100 μM), β-phenylethylamine had no effect on extracellular metabolite levels of dopamine and 5-HT. The results suggest that β-phenylethylamine increases the efflux of monoamines, preferentially dopamine, without affecting monoamine metabolism, in the nucleus accumbens.

Revue / Journal Title

European journal of pharmacology   ISSN 0014-2999   CODEN EJPHAZ 

Source / Source

1998, vol. 349, n^o2-3, pp. 163-169 (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1967) (Revue)

Mots-clés anglais / English Keywords

Dopamine ; Serotonin ; Metamfetamine ; Nucleus accumbens ; Microdialysis ; Animal ; Rat ; Biological activity ; Mechanism of action ; Rodentia ; Mammalia ; Vertebrata ;

Mots-clés français / French Keywords

Dopamine ; Sérotonine ; Métamfétamine ; Noyau accumbens ; Microdialyse ; Animal ; Rat ; Activité biologique ; Mécanisme action ; β-Phényléthylamine ; Rodentia ; Mammalia ; Vertebrata ;

Mots-clés espagnols / Spanish Keywords

Dopamina ; Serotonina ; Metanfetamina ; Núcleo acumbens ; Microdiálisis ; Animal ; Rata ; Actividad biológica ; Mecanismo acción ; Rodentia ; Mammalia ; Vertebrata ;

Localisation / Location

INIST-CNRS, Cote INIST : 13322, 35400007689053.0050