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Titre du document / Document title

Characterization of β-phenylethylamine-induced monoamine release in rat nucleus accumbens : a microdialysis study

Auteur(s) / Author(s)

NAKAMURA M. (1) ; ISHII A. (2) ; NAKAHARA D. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Psychology, Hamamatsu University School of Medicine, 3600 Honda-cho, Hamamatsu 431-3192, JAPON
(2) Department of Legal Medicine, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, JAPON

Résumé / Abstract

In vivo microdialysis was used to investigate the effect of β-phenylethylamine on extracellular levels of monoamines and their metabolites in the nucleus accumbens of conscious rats. At all doses tested (1, 10 and 100 μM), infusion of β-phenylethylamine through the microdialysis probe significantly increased extracellular levels of dopamine in the nucleus accumbens. These increases were dose-related. The increase in dopamine levels induced by 100 μM β-phenylethylamine was not affected by co-perfusion of 4 μM tetrodotoxin. The ability of 100 μM β-phenylethylamine to increase the extracellular level of dopamine was comparable to that of the same dose of methamphetamine. On the other hand, β-phenylethylamine had a much less potent enhancing effect on 5-hydroxytryptamine (5-HT) than dopamine levels. Only the highest dose (100 μM) caused a statistically significant effect on 5-HT levels. Over the dose range tested (1, 10 and 100 μM), β-phenylethylamine had no effect on extracellular metabolite levels of dopamine and 5-HT. The results suggest that β-phenylethylamine increases the efflux of monoamines, preferentially dopamine, without affecting monoamine metabolism, in the nucleus accumbens.

Revue / Journal Title

European journal of pharmacology    ISSN  0014-2999   CODEN EJPHAZ 

Source / Source

1998, vol. 349, no2-3, pp. 163-169 (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1967) (Revue)

Mots-clés anglais / English Keywords

Dopamine

;

Serotonin

;

Metamfetamine

;

Nucleus accumbens

;

Microdialysis

;

Animal

;

Rat

;

Biological activity

;

Mechanism of action

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés français / French Keywords

Dopamine

;

Sérotonine

;

Métamfétamine

;

Noyau accumbens

;

Microdialyse

;

Animal

;

Rat

;

Activité biologique

;

Mécanisme action

;

β-Phényléthylamine

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés espagnols / Spanish Keywords

Dopamina

;

Serotonina

;

Metanfetamina

;

Núcleo acumbens

;

Microdiálisis

;

Animal

;

Rata

;

Actividad biológica

;

Mecanismo acción

;

Rodentia

;

Mammalia

;

Vertebrata

;

Localisation / Location

INIST-CNRS, Cote INIST : 13322, 35400007689053.0050

Nº notice refdoc (ud4) : 2350263



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