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Titre du document / Document title

A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod

Auteur(s) / Author(s)

TYRING S. K. ; ARANY I. ; STANLEY M. A. ; TOMAI M. A. ; MILLER R. L. ; SMITH M. H. ; MCDERMOTT D. J. ; SLADE H. B. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Departments of Microbiology/Immunology and Dermatology, University of Texas Medical Branch at Galveston, ETATS-UNIS
Department of Pathology, University of Cambridge, Cambridge, ROYAUME-UNI
Departments of Pharmacology and Clinical Research, 3M Pharmaceuticals, St. Paul, Minnesota, ETATS-UNIS

Résumé / Abstract

Imiquimod, an immune response modifier, has been demonstrated to be safe and effective in the treatment of external genital and perianal warts caused by human papillomavirus (HPV). To identify the molecular mechanism(s) by which condylomata acuminata clear during topical treatment with imiquimod, wart skin biopsies were taken from patients before treatment, at treatment week 6, and at the end of treatment. Tissues were analyzed for HPV DNA and for mRNA of several cytokines and HPV gene products. Wart clearance was associated with evidence of tissue production of interferon-α, -β, and -γ and tumor necrosis factor-α. Regression of warts was strongly associated with a decrease in HPV DNA and in mRNA expression for both early and late viral proteins. Thus, topical imiquimod treatment of anogenital warts led to significant increases in local production of multiple interferon mRNAs and a significant reduction in virus load as measured by decreases in HPV DNA and mRNA for early HPV proteins.

Revue / Journal Title

The Journal of infectious diseases    ISSN  0022-1899   CODEN JIDIAQ 

Source / Source

1998, vol. 178, no2, pp. 551-555 (14 ref.)

Langue / Language

Anglais

Editeur / Publisher

Oxford University Press, Oxford, ROYAUME-UNI  (1904) (Revue)

Mots-clés anglais / English Keywords

Human papillomavirus

;

Molecular epidemiology

;

Wart

;

Messenger RNA

;

Cytokine

;

Antigen

;

Protein

;

Human

;

Treatment

;

Local administration

;

Condyloma acuminatum

;

Imiquimod

;

Viral load

;

Papillomavirus

;

Papovaviridae

;

Virus

;

Viral disease

;

Infection

;

Sexually transmitted disease

;

Genital diseases

;

Immunomodulator

;

Antiviral

;

Mots-clés français / French Keywords

Papillomavirus humain

;

Epidémiologie moléculaire

;

Verrue

;

RNA messager

;

Cytokine

;

Antigène

;

Protéine

;

Homme

;

Traitement

;

Voie locale

;

Condylome acuminé

;

Imiquimod

;

Charge virale

;

Papillomavirus

;

Papovaviridae

;

Virus

;

Virose

;

Infection

;

Maladie sexuellement transmissible

;

Appareil génital pathologie

;

Immunomodulateur

;

Antiviral

;

Mots-clés espagnols / Spanish Keywords

Human papillomavirus

;

Epidemiología molecular

;

Verruga

;

RNA mensajero

;

Citoquina

;

Antígeno

;

Proteína

;

Hombre

;

Tratamiento

;

Vía local

;

Condiloma acuminado

;

Imiquimod

;

Papillomavirus

;

Papovaviridae

;

Virus

;

Virosis

;

Infección

;

Enfermedad de transmisión sexual

;

Aparato genital patología

;

Inmunomodulador

;

Antiviral

;

Localisation / Location

INIST-CNRS, Cote INIST : 2052, 35400007262927.0360

Nº notice refdoc (ud4) : 2343172



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