Titre du document / Document title

Is the single use of intraoperative 5-fluorouracil in filtering surgery for high-risk cases enough ?

Auteur(s) / Author(s)

WATTS P. ⁽¹⁾ ; KARIA N. ⁽¹⁾ ; MCALLISTER J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Prince Charles Eye Unit, King Edward VII Hospital, Windsor SL4 3DP, ROYAUME-UNI

Résumé / Abstract

Purpose To study the efficacy of the adjunctive use of a single intraoperative application of 5-fluorouracil (5FU) in eyes with poor prognoses for a successful outcome with a trabeculectomy. Method Twenty-four patients (25 eyes) with a mean age of 63.7 ± 14.7 years (range 27-86 years) and a history of one or more risk factors (age <50 years, more than 3 years on topical medication, a previous failed filter, previous cataract surgery, uveitis, neovascular glaucoma) underwent trabeculectomy with the intraoperative application of 5FU on a sponge (25 mg/ml) for 5 min. The average follow-up was 10.1 ± 5.5 months. Results The mean pre-operative intraocular pressure (IOP) was 24.7 ± 6.2 mmHg and the mean post-operative IOP was 13.9 ± 3.5 mmHg. Success, defined as an IOP within desired target levels for a particular eye, in the presence of a functioning filter, without supplementary medical therapy, was achieved in 56.5% of cases. Conclusions Our results of successful filters in this group of patients with moderate- to high-risk characteristics approach similar figures quoted for trabeculectomies without the adjunctive use of infraoperative 5FU in eyes with poor prognoses with a similar length of follow-up. Though the numbers are small there is a trend that indicates that the intraoperative application of a single dose of 5 FU alone may not be sufficient in eyes with moderate- to high-risk characteristics of failure of a trabeculectomy.

Revue / Journal Title

Eye   ISSN 0950-222X   CODEN EYEEEC 

Source / Source

1998, vol. 12 (3A), pp. 374-378 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing Group, Basingstoke, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Glaucoma (eye) ; Trabeculectomy ; Fluorouracil ; Antineoplastic agent ; Antimetabolic ; Single dose ; Chemotherapy ; Treatment ; Intraoperative ; Human ; Fluoropyrimidine derivatives ; Eye disease ; Surgery ; Administration schedule ;

Mots-clés français / French Keywords

Glaucome ; Trabéculectomie ; Fluorouracil ; Anticancéreux ; Antimétabolite ; Dose unique ; Chimiothérapie ; Traitement ; Peropératoire ; Homme ; Fluoropyrimidine dérivé ; Oeil pathologie ; Chirurgie ; Rythme administration ;

Mots-clés espagnols / Spanish Keywords

Glaucoma (ojo) ; Trabeculectomía ; Fluorouracilo ; Anticanceroso ; Antimetabólito ; Dosis única ; Quimioterapia ; Tratamiento ; Peroperatorio ; Hombre ; Fluoropirimidina derivado ; Ojo patología ; Cirugía ; Ritmo administración ;

Localisation / Location

INIST-CNRS, Cote INIST : 21076, 35400007712699.0080