Titre du document / Document title
Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis
Auteur(s) / Author(s)
JIMENEZ-JIMENEZ F. J. (1) ;
DE BUSTOS F. (2) ;
MOLINA J. A. (3) ;
DE ANDRES C. (4) ;
GASALLA T. (1) ;
ORTI-PAREJA M. (1) ;
ZURDO M. (1) ;
PORTA J. (3) ;
CASTELLANO-MILLAN F. (1) ;
ARENAS J. (2) ;
DE SALAMANCA R. E. (1 5) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Neurology Hospital Universitario 'Príncipe do Asturias', Alcalá de Henares, Madrid, ESPAGNE
(2) Department of Biochemistry, Hospital Doce de Octubre, Madrid, ESPAGNE
(3) Department of Neurology, Hospital Doce de Octubre, Madrid, ESPAGNE
(4) Department of Neurology, Hospital General Universitario Gregorio Marañón, Madrid, ESPAGNE
(5) Department of Medicine, Universidad Complutense, Madrid, ESPAGNE
Résumé / Abstract
We compared cerebrospinal fluid (CSF) and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 36 patients with multiple sclerosis (MS) and 32 matched controls. The mean CSF vitamin E levels and the CSF/ serum vitamin E ratio did not differ significantly between the two study groups. The serum levels of vitamin E and the serum vitamin E/cholesterol ratio were significantly lower in MS patients when compared with controls (P < 0.05 and P < 0.01, respectively). These values were not correlated with age, age at onset and duration of the disease in the patients group. These results suggest that CSF vitamin E concentrations are not a marker of activity of MS activity.
Revue / Journal Title
Neuroscience letters
ISSN
0304-3940
CODEN NELED5
Source / Source
1998, vol. 249, n
o1, pp. 65-67 (16 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Shannon, IRLANDE
(1975)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 17240, 35400007227128.0170
Nº notice refdoc (ud4) : 2324921
