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Titre du document / Document title

Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis

Auteur(s) / Author(s)

JIMENEZ-JIMENEZ F. J. (1) ; DE BUSTOS F. (2) ; MOLINA J. A. (3) ; DE ANDRES C. (4) ; GASALLA T. (1) ; ORTI-PAREJA M. (1) ; ZURDO M. (1) ; PORTA J. (3) ; CASTELLANO-MILLAN F. (1) ; ARENAS J. (2) ; DE SALAMANCA R. E. (1 5) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Neurology Hospital Universitario 'Príncipe do Asturias', Alcalá de Henares, Madrid, ESPAGNE
(2) Department of Biochemistry, Hospital Doce de Octubre, Madrid, ESPAGNE
(3) Department of Neurology, Hospital Doce de Octubre, Madrid, ESPAGNE
(4) Department of Neurology, Hospital General Universitario Gregorio Marañón, Madrid, ESPAGNE
(5) Department of Medicine, Universidad Complutense, Madrid, ESPAGNE

Résumé / Abstract

We compared cerebrospinal fluid (CSF) and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 36 patients with multiple sclerosis (MS) and 32 matched controls. The mean CSF vitamin E levels and the CSF/ serum vitamin E ratio did not differ significantly between the two study groups. The serum levels of vitamin E and the serum vitamin E/cholesterol ratio were significantly lower in MS patients when compared with controls (P < 0.05 and P < 0.01, respectively). These values were not correlated with age, age at onset and duration of the disease in the patients group. These results suggest that CSF vitamin E concentrations are not a marker of activity of MS activity.

Revue / Journal Title

Neuroscience letters    ISSN  0304-3940   CODEN NELED5 

Source / Source

1998, vol. 249, no1, pp. 65-67 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1975) (Revue)

Mots-clés anglais / English Keywords

Cerebrospinal fluid

;

Serum

;

α-Tocopherol

;

Multiple sclerosis

;

Human

;

Antioxidant

;

Vitamin

;

Nervous system diseases

;

Central nervous system disease

;

Inflammatory disease

;

Immunopathology

;

Autoimmune disease

;

Mots-clés français / French Keywords

Liquide céphalorachidien

;

Sérum

;

α-Tocophérol

;

Sclérose en plaque

;

Homme

;

Antioxydant

;

Vitamine

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Maladie inflammatoire

;

Immunopathologie

;

Maladie autoimmune

;

Mots-clés espagnols / Spanish Keywords

Líquido cefalorraquídeo

;

Suero

;

α-Tocoferol

;

Esclerosis en placa

;

Hombre

;

Antioxidante

;

Vitamina

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Enfermedad inflamatoria

;

Inmunopatología

;

Enfermedad autoinmune

;

Localisation / Location

INIST-CNRS, Cote INIST : 17240, 35400007227128.0170

Nº notice refdoc (ud4) : 2324921



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