Titre du document / Document title

Elevated levels of basal estradiol-17β predict poor response in patients with normal basal levels of follicle-stimulating hormone undergoing in vitro fertilization

Auteur(s) / Author(s)

EVERS J. L. H. ⁽¹⁾ ; SLAATS P. ⁽¹⁾ ; LAND J. A. ⁽¹⁾ ; DUMOULIN J. C. M. ⁽¹⁾ ; DUNSELMAN G. A. J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Reproductive Endocrinology and Fertility, Department of Obstetrics and Gynecology, Academisch Ziekenhuis Maastricht and The University of Maastricht, Maastricht, PAYS-BAS

Résumé / Abstract

Objective: To evaluate whether the predictive ability of a normal FSH level on cycle day 3 can be enhanced by levels of estradiol-17β (E₂) on cycle day 3. Design: Prospective cohort study. Setting: University hospital-based. tertiary care infertility center. Patient(s): Two hundred thirty-one consecutively seen patients who attended the center for their first IVF attempt. Intervention(s): Blood samples were collected on day 3 of the cycle preceding IVF: IVF was performed in all patients. Main Outcome Measure(s): Patient's age, number of ampules of hMG, cancellation rate, number of oocytes. fertilization rate, and clinical pregnancy rate. Result(s): In patients with elevated FSH levels on cycle day 3, a low oocyte yield was achieved (7 versus 11) and a high number of ampules of hMG was necessary (56 versus 33). Their cancellation rate was high (67% versus 16%). In patients with normal basal FSH levels. high E_z levels predicted a high cancellation rate (56^C7r. versus 13% in patients with low E₂ levels) and a low oocyte yield (9. versus 11 in patients with low E₂levels). Patients with both normal FSH levels and low E₂ levels on cycle day 3 fared best. Conclusion(s): The basal E₂ level on cycle day 3 is a useful prognosticatur of response to stimulation in IVF patients with normal basal FSH levels.

Revue / Journal Title

Fertility and sterility   ISSN 0015-0282   CODEN FESTAS 

Source / Source

1998, vol. 69, n^o6, pp. 1010-1014 (9 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, New York, NY, ETATS-UNIS  (1950) (Revue)

Mots-clés anglais / English Keywords

Negative therapeutic reaction ; Gonadotropin ; Hormonal investigation ; FSH ; 17β-Estradiol ; Prognosis ; Ovulation ; Induction ; Human ; Female ; Assisted procreation ; Adenohypophyseal hormone ; Estrogen ; Ovarian hormone ;

Mots-clés français / French Keywords

Résistance traitement ; Gonadotrophine ; Exploration hormonale ; FSH ; 17β-Oestradiol ; Pronostic ; Ovulation ; Induction ; Homme ; Femelle ; Procréation assistée ; Hormone adénohypophysaire ; Oestrogène ; Hormone ovarienne ;

Mots-clés espagnols / Spanish Keywords

Resistencia al tratamiento terapeútico ; Gonadotropina ; Análisis hormonal ; FSH ; 17β-Estradiol ; Pronóstico ; Ovulación ; Inducción ; Hombre ; Hembra ; Procreación asistida ; Hormona adenohipofisaria ; Estrógeno ; Hormona ovárica ;

Localisation / Location

INIST-CNRS, Cote INIST : 4120, 35400007566277.0060