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Titre du document / Document title

Onset and Exacerbation of Obsessive-Compulsive Disorder in Pregnancy and the Postpartum Period

Auteur(s) / Author(s)

FORRAY Ariadna (1) ; FOCSENEANU Mariel (1 3) ; PITTMAN Brian (1) ; MCDOUGLE Christopher J. (4) ; EPPERSON C. Neill (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, ETATS-UNIS
(2) Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, ETATS-UNIS
(3) Department of Obstetrics and Gynecology, New York Hospital-Weill Cornell Medical Center, New York, ETATS-UNIS
(4) Department of Psychiatry, Indiana University School of Medicine, Indianapolis, ETATS-UNIS

Résumé / Abstract

Background: The primary goal of this study was to examine the impact of pregnancy, childbirth, and menstruation on the onset of obsessive-compulsive disorder (OCD) and/or exacerbation of OCD symptoms. Method: One hundred twenty-six women aged between 18 and 69 years attending a university-based OCD clinic who met DSM-IV criteria for OCD according to the Structured Clinical Interview for DSM-IV Disorders were interviewed retrospectively to assess OCD onset and symptom exacerbation in relationship to reproductive events. Women were placed into 2 groups: those who had ever been pregnant (ever pregnant group) and those who had never been pregnant. The ever pregnant group was further subdivided into those who reported onset of OCD in the perinatal period (perinatal-related group) and those who denied onset related to pregnancy (nonperinatal-related group). Between-group comparisons were done using a Student t test for continuous measures, and categorical variables were assessed using the χ2 test. Results: Of the 78 women in the ever pregnant group, 32.1% (n = 24) had OCD onset in the perinatal period (perinatal-related group), 15.4% in pregnancy, 14.1% at postpartum, and 1.3% after miscarriage. Of 132 total pregnancies, 34.1% involved an exacerbation of symptoms, 22.0% involved an improvement in OCD symptoms, and 43.9% did not change symptom severity in women with preexisting illness. Women in the perinatal-related group and women with perinatal worsening of preexisting OCD were more likely to have premenstrual worsening of OCD symptoms compared to women in the nonperinatal-related group (66% vs 39%, P=.047). Conclusions: Findings from this study provide additional evidence that pregnancy and childbirth are frequently associated with the onset of OCD or worsening of symptoms in those with preexisting disorder. In addition, there appears to be continuity between OCD onset and/or exacerbation across the reproductive life cycle, at least with menstruation and pregnancy.

Revue / Journal Title

The Journal of clinical psychiatry    ISSN  0160-6689 

Source / Source

2010, vol. 71, no8, pp. 1061-1068 [8 page(s) (article)] (39 ref.)

Langue / Language

Anglais

Editeur / Publisher

Physicians Postgraduate Press, Memphis, TN, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Anxiety disorder

;

Puerperium

;

Pregnancy

;

Obsessive compulsive disorder

;

Mots-clés français / French Keywords

Trouble anxieux

;

Postpartum

;

Gestation

;

Obsession compulsion

;

Mots-clés espagnols / Spanish Keywords

Trastorno ansiedad

;

Postparto

;

Gestación

;

Obsesión compulsión

;

Localisation / Location

INIST-CNRS, Cote INIST : 9069, 35400019260752.0140

Nº notice refdoc (ud4) : 23170320



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