Titre du document / Document title

Controlled-release morphine tablets in patients with chronic cancer pain : A narrative review of controlled clinical trials

Auteur(s) / Author(s)

WARFIELD C. A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Pain Management Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, ETATS-UNIS

Résumé / Abstract

BACKGROUND. Controlled-release (CR) morphine tablets have become routine therapy in the management of cancer pain. Compared with immediate-release (IR) morphine, this formulation provides the benefit of dosing every 12 hours. METHODS. This study reviewed the 10 published, well controlled, repeated-dose, comparative studies with CR morphine tablets administered every 12 hours to patients with cancer pain. RESULTS. CR morphine tablets were uniformly effective; 98% of patients completed a treatment course of every-12-hours therapy. Although the effective analgesic dose varied considerably from study to study (range, 90-330 mg per day), pain was well controlled with CR morphine tablets as the primary analgesic. Mean pain scores, converted to a common 10-point scale, ranged from 1.1-2.9 across all studies. There was only occasional need for IR morphine rescue medication (range, 2-39 mg per day). The mean discontinuation rate because of side effects or lack of every-12-hours efficacy was 2%. In seven studies that used IR morphine as the comparative agent, CR morphine tablets were found to be equally effective as IR morphine. CONCLUSIONS. Twice-daily dosing of CR morphine provides convenient, safe, and effective relief of cancer pain.

Revue / Journal Title

Cancer   ISSN 0008-543X   CODEN CANCAR 

Source / Source

1998, vol. 82, n^o12, pp. 2299-2306 (37 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Liss, New York, NY, ETATS-UNIS  (1948) (Revue)

Mots-clés anglais / English Keywords

Malignant tumor ; Pain ; Chronic ; Morphine ; Analgesic ; Application method ; Treatment ; Controlled release form ; Tablet ; Clinical trial ; Review ; Human ; Opiates ;

Mots-clés français / French Keywords

Tumeur maligne ; Douleur ; Chronique ; Morphine ; Analgésique ; Modalité traitement ; Traitement ; Forme libération contrôlée ; Comprimé ; Essai clinique ; Article synthèse ; Homme ; Opiacés ;

Mots-clés espagnols / Spanish Keywords

Tumor maligno ; Dolor ; Crónico ; Morfina ; Analgésico ; Modalidad tratamiento ; Tratamiento ; Forma liberación controlada ; Tableta ; Ensayo clínico ; Artículo síntesis ; Hombre ; Opiados ;

Localisation / Location

INIST-CNRS, Cote INIST : 2701, 35400007693832.0010