Titre du document / Document title
The use of corticosteroids for choroidal neovascularisation in young patients
Auteur(s) / Author(s)
FLAXEL C. J.
(1) ;
OWENS S. L.
(1) ;
MULHOLLAND B.
(1) ;
SCHWARTZ S. D.
(1) ;
GREGOR Z. J.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Moorfields Eye Hospital, City Road, London EC1V 2PD, ROYAUME-UNI
Résumé / Abstract
Purpose To investigate the role of systemic corticosteroids in the treatment of sight-threatening choroidal neovascularisation (CNV) in patients with punctate inner choroidopathy (PIC) and multifocal inner choroiditis (MIC). Methods Twelve eyes of 10 patients with evidence of PIC or MIC with recent visual symptoms were identified. All eyes had CNV within the foveal avascular zone on fundus fluorescein angiography (FFA). Systemic oral prednisolone at an initial dose of 1 mg/kg (60-80 mg) was given for 3-5 days and the dose was subsequently tapered. Changes in best corrected visual acuity and leakage on FFA were recorded during follow-up. Systemic side-effects of the corticosteroids were monitored. Results In 10 of 12 eyes vision improved or stabilised. Leakage on FFA resolved in 9 eyes and was reduced in 3. Four patients required more than one course of oral corticosteroids. One patient was maintained on low-dose oral corticosteroids for recurrent CNV activity. No systemic complications from the treatment were observed. Conclusion A course of oral corticosteroids in healthy young patients with subfoveal CNV in PIC or MIC may reduce subretinal vascular leakage and stabilise vision when no other proven treatment option is available.
Revue / Journal Title
Eye
ISSN 0950-222X
CODEN EYEEEC
Source / Source
1998, vol. 12 (2), pp. 266-272 (36 ref.)
Langue / Language
Anglais
Editeur / Publisher
Nature Publishing Group, Basingstoke, ROYAUME-UNI
(1987)
(Revue)
Mots-clés anglais / English Keywords
Neovascularization ;
Choroid ;
Corticosteroid ;
Treatment ;
Chemotherapy ;
Oral administration ;
Treatment efficiency ;
Human ;
Punctate inner choroïdopathy ;
Multifocal inner choroiditis ;
Eye disease ;
Uvea disease ;
Mots-clés français / French Keywords
Néovascularisation ;
Choroïde ;
Corticostéroïde ;
Traitement ;
Chimiothérapie ;
Voie orale ;
Efficacité traitement ;
Homme ;
Choroïdopathie ponctuée interne ;
Choroïdite multifocale interne ;
Oeil pathologie ;
Uvée pathologie ;
Mots-clés espagnols / Spanish Keywords
Neovascularización ;
Coroides ;
Corticoesteroide ;
Tratamiento ;
Quimioterapia ;
Vía oral ;
Eficacia tratamiento ;
Hombre ;
Ojo patología ;
Uvea patología ;
Localisation / Location
INIST-CNRS, Cote INIST : 21076, 35400007643894.0210
Nº notice refdoc (ud4) : 2271620
