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Titre du document / Document title

Neuroendokrines Karzinom der Lunge: eine diagnostische und therapeutische Herausforderung = Neuroendocrine Carcinoma of the Lung: a Diagnostic and Therapeutic Challenge

Auteur(s) / Author(s)

Böttger Claudia (1) ; Warth Arne (2) ; Nawroth Peter P. (1) ; Isermann Berend (1 3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Innere Medizin I und Klinische Chemie, Universität Heidelberg, Heidelberg, Germany
(2) Pathologische Institut, Universität Heidelberg, Heidelberg, Germany
(3) Innere Medizin I und Klinische Chemie, Universität Heidelberg, 69120, Heidelberg, Germany

Résumé / Abstract

A 53-year-old female patient presented with cough and hoarseness for 3 years. Based on a biopsy of a bronchial tumor, a small cell neuroendocrine tumor of the lung was diagnosed and chemotherapy with etoposide and cisplatin was initiated. As the tumor progressed under chemotherapy, the bronchial biopsy was reevaluated and further biopsies of liver and adrenal metastases were obtained. The diagnosis was corrected, and an atypical neuroendocrine bronchial carcinoma was diagnosed. Under octreotide therapy, the patient remained stable for 1 year, when a discrete progress of the primary tumor in the lung was observed. Treatment with the mTOR (mammalian target of rapamycin) inhibitor everolimus was then initiated. Based on this case, the diagnostic criteria, prognostic factors and therapeutic options of neuroendocrine bronchial carcinomas are discussed.

Revue / Journal Title

Medizinische Klinik    ISSN  1615-6722 

Source / Source

2010, vol. 105, no4, pp. 237-241 [5 page(s) (article)]

Langue / Language

Allemand

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (2000) (Revue)

Mots-clés d'auteur / Author Keywords

Neuroendocrine tumor

;

Bronchial carcinoma

;

Octreotide

;

mTOR inhibitor

;

Localisation / Location

35400060455608.0020

Urban & Vogel, Muenchen, 2010
Nº notice refdoc (ud4) : 22623194



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