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Titre du document / Document title

Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl

Auteur(s) / Author(s)

MUHAMMAD KHALID SAEED (1) ; YULIN DENG (2) ; RONGJI DAI (2) ; WEI LI (2) ; YUHONG YU (2) ; IQBAL Zafar (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) FBRC, Pakistan Council of Scientific and Industrial Research (PCSIR), Labs Complex, Lahore, PAKISTAN
(2) School of Life Sciences and Technology, Beijing Institute of Technology (BIT), Beijing 100081, CHINE
(3) ACRC, Pakistan Council of Scientific and Industrial Research (PCSIR), Labs Complex, Lahore, PAKISTAN

Résumé / Abstract

Torreya grandis (Taxaceae) was studied for antinociceptive and anti-inflammatory effects. Leaves were extracted with 80% ethanol at 80°C for 3 h and fractionated with petroleum ether, chloroform, ethylacetate and n-butanol. The aqueous ethanolic extract (aq.EE), ethylacetate fraction (EaF) and butanol fraction (BtF) at the doses of (100 and 200 mg/kg, i.g.) body weight were used for study. Evaluation of antinociceptive activity was carried out by acetic acid-induced writhing response and formalin-induced paw licking time in the first and second phases of mice. The paw edema induced by formalin- and xylene-induced ear edema were used to assess anti-inflammatory activity. It was found that Torreya grandis extract and fractions at the doses of (100 and 200 mg/kg, i.g.) were significantly attenuated the writhing responses induced by acetic acid and second phase of pain response induced by subplantar injection of formalin in mice. In addition, these extract and fractions inhibiting the formaldehyde-induced arthritis as well as xylene-induces edema prolifically. From acute oral toxicity studies no mortality was pragmatic even at highest dose (2500 mg/kg, i.g.). Furthermore, our phytochemical studies indicated that the aq. ethanolic extract of leaves contains alkaloids, flavonoids, tannins, terpenoids and saponins. The results provide justification for the folkloric uses of Torreya grandis in the treatment of analgesic and inflammatory-based diseases across the China.

Revue / Journal Title

Journal of ethnopharmacology    ISSN  0378-8741   CODEN JOETD7 

Source / Source

2010, vol. 127, no2, pp. 414-418 [5 page(s) (article)] (3/4 p.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1978) (Revue)

Mots-clés anglais / English Keywords

Plant origin

;

Medicinal plant

;

Pharmacognosy

;

Plant leaf

;

Extract

;

Antiinflammatory agent

;

Analgesic

;

Mots-clés français / French Keywords

Origine végétale

;

Plante médicinale

;

Pharmacognosie

;

Feuille végétal

;

Extrait

;

Antiinflammatoire

;

Analgésique

;

Mots-clés espagnols / Spanish Keywords

Origen vegetal

;

Planta medicinal

;

Farmacognosia

;

Hoja vegetal

;

Extracto

;

Antiinflamatorio

;

Analgésico

;

Mots-clés d'auteur / Author Keywords

Antinociceptive

;

Anti-inflammatory

;

Torreya grandis

;

Localisation / Location

INIST-CNRS, Cote INIST : 18028, 35400019011163.0310

Nº notice refdoc (ud4) : 22473674



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