Titre du document / Document title

Assessment of a tablet drug delivery system incorporating nonoxynol-9 coprecipitated with polyvinylpyrrolidone in preventing the onset of pregnancy in rabbits

Auteur(s) / Author(s)

ZAVOS P. M. ⁽¹⁾ ; CORREA J. R. ⁽¹⁾ ; ZARMAKOUPIS-ZAVOS P. N. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Animal Sciences, University of Kentucky, Lexington, Kentucky, ETATS-UNIS

Résumé / Abstract

Objective: To assess the in vivo efficacy of the tablet drug delivery system containing nonoxynol-9 coprecipitated with polyvinylpyrrolidone by delivering the spermicidal agents vaginally and evaluating their ability to prevent the onset of pregnancy in rabbits. Design: Controlled clinical study. Setting: Division of Laboratory and Animal Resources, College of Pharmacy, University of Kentucky. Animal(s): Forty-two New Zealand White female rabbits. Intervention(s): The rabbits were artificially inseminated at various intervals after vaginal insertion of the tablet drug delivery system containing either polyvinylpyrrolidone only (0 minutes) or nonoxynol-9 coprecipitated with polyvinylpyrrolidone (polyvinylpyrrolidone/nonoxynol-9; 0, 3, 30, 180, and 360 minutes). The rabbits were induced to ovulate 6 hours before insemination by IM injection of hCG (200 IU). Main Outcome Measure(s): The onset of pregnancy in the rabbits was evaluated after insertion of the tablet drug delivery system containing polyvinylpyrrolidone only or polyvinylpyrrolidone/nonoxynol-9 at various intervals, followed by artificial insemination. Result(s): The onset of pregnancy was not reduced significantly when the tablet drug delivery system containing polyvinylpyrrolidone or polyvinylpyrrolidone/nonoxynol-9 was used and insemination was performed immediately after tablet insertion (time 0). However, pregnancy rates (PRs) were reduced significantly in the rabbits that received the tablet drug delivery system containing polyvinylpyrrolidone/nonoxynol-9 and were inseminated at 3, 30, 180, and 360 minutes after tablet insertion. The highest PR reduction occurred between 30 and 180 minutes after insertion of the tablet drug delivery system containing polyvinylpyrrolidone/nonoxynol-9. Conclusion(s): The tablet drug delivery system is an efficient method of delivering the tested spermicidal agents vaginally. The design and dosage used in preparing the tablet drug delivery system provide short- and lung-term release of the spermicidal agents, which results in almost immediate and extended enhancement of their contraceptive properties.

Revue / Journal Title

Fertility and sterility   ISSN 0015-0282   CODEN FESTAS 

Source / Source

1998, vol. 69, n^o4, pp. 768-773 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, New York, NY, ETATS-UNIS  (1950) (Revue)

Mots-clés anglais / English Keywords

Tablet ; Intravaginal administration ; Release ; Active ingredient ; Pyrrolidone(vinyl) polymer ; Prevention ; Biological activity ; Nonoxinol ; In vitro ; Rabbit ; Pregnancy ; Contraceptive ; Spermicide ; Lagomorpha ; Mammalia ; Vertebrata ;

Mots-clés français / French Keywords

Comprimé ; Voie intravaginale ; Libération ; Principe actif ; Pyrrolidone(vinyl) polymère ; Prévention ; Activité biologique ; Nonoxinol ; In vitro ; Lapin ; Gestation ; Contraceptif ; Spermicide ; Lagomorpha ; Mammalia ; Vertebrata ;

Mots-clés espagnols / Spanish Keywords

Tableta ; Vía intravaginal ; Liberación ; Principio activo ; Pirrolidona(vinil) polímero ; Prevención ; Actividad biológica ; Nonoxinol ; In vitro ; Conejo ; Gestación ; Anticonceptivo ; Espermicida ; Lagomorpha ; Mammalia ; Vertebrata ;

Localisation / Location

INIST-CNRS, Cote INIST : 4120, 35400007535033.0250