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Titre du document / Document title

Dissociation of decision-making under ambiguity and decision-making under risk in patients with Parkinson's disease: A neuropsychological and psychophysiological study

Auteur(s) / Author(s)

EUTENEUER Frank (1) ; SCHAEFER Florian (1) ; STUERMER Ralf (1) ; BOUCSEIN Wolfram (1) ; TIMMERMANN Lars (2) ; BARBE Michael T. (2 3) ; EBERSBACH Georg (4) ; OTTO Jörg (4) ; KESSLER Josef (2) ; KALBE Elke (2 3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Physiological Psychology, University of Wuppertal, ALLEMAGNE
(2) Department of Neurology, University Hospital of Cologne, ALLEMAGNE
(3) Institute ofNeuroscience and Medicine Research (INM-3), Cognitive Neurology Section, Research Centre Juelich, ALLEMAGNE
(4) Movement Disorders Clinic, Beelitz-Heilstätten, ALLEMAGNE

Résumé / Abstract

Decision-making impairments in Parkinson's disease (PD) are most likely associated with dysfunctions in fronto-striatal loops. Recent studies examined decision-making in PD either in ambiguous situations with implicit rules, using the Iowa Gambling Task (IGT), or in risky situations with explicit rules, using the Game of Dice Task (GDT). Both tasks have been associated with the limbic-orbitofrontal-striatal loop, involved in emotional processing. However, the GDT has additionally been highly associated with the dorsolateral prefrontal-striatal loop, being involved in executive functions. The present study is the first one which examined decision-making in PD patients with both, IGT and GDT. We studied 21 non-demented PD patients on dopaminergic medication and 23 healthy controls with both tasks and a neuropsychological test battery with focus on executive functions. To analyse possible abnormalities in emotional processing, electrodermal responses (EDRs) were assessed while performing the tasks. We found that PD patients were significantly impaired in the GDT, but not in the IGT. Executive dysfunctions correlated with GDT but not with IGT performance. In both tasks, PD patients showed significantly reduced feedback EDRs after losses, but not after gains, indicating a primary decline of sensitivity to negative feedback. Our behavioural data suggest that dysfunctions in the dorsolateral prefrontal loop might be stronger than in the limbic loop, resulting in deficits in executive functions and GDT performance but unimpaired IGT performance. Reduced sensitivity to negative feedback is discussed with regard to dysfunctions in the limbic loop, which may result from pathology of limbic structures or dopaminergic medication.

Revue / Journal Title

Neuropsychologia    ISSN  0028-3932   CODEN NUPSA6 

Source / Source

2009, vol. 47, no13, pp. 2882-2890 [9 page(s) (article)] (1 p.1/2)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1963) (Revue)

Mots-clés anglais / English Keywords

Psychometrics

;

Nervous system diseases

;

Central nervous system disease

;

Degenerative disease

;

Extrapyramidal syndrome

;

Cerebral disorder

;

Human

;

Electrodermography

;

Idiopathic

;

Play

;

Iowa Gambling Test

;

Neuropsychological test

;

Psychophysiology

;

Parkinson disease

;

Ambiguity

;

Decision making

;

Dissociation

;

Mots-clés français / French Keywords

Psychométrie

;

Pathologie du système nerveux

;

Pathologie du système nerveux central

;

Maladie dégénérative

;

Syndrome extrapyramidal

;

Pathologie de l'encéphale

;

Homme

;

Electrodermographie

;

Idiopathique

;

Jeu

;

Iowa Gambling Test

;

Test neuropsychologique

;

Psychophysiologie

;

Maladie de Parkinson

;

Ambiguité

;

Prise de décision

;

Dissociation

;

Mots-clés espagnols / Spanish Keywords

Psicometría

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Enfermedad degenerativa

;

Extrapiramidal síndrome

;

Encéfalo patología

;

Hombre

;

Electrodermografía

;

Idiopático

;

Juego

;

Iowa Gambling Test

;

Prueba neuropsichologica

;

Psicofisiología

;

Parkinson enfermedad

;

Ambiguedad

;

Toma decision

;

Disociación

;

Mots-clés d'auteur / Author Keywords

Iowa Gambling Task

;

Game of Dice Task

;

Idiopathic Parkinson Syndrome

;

Electrodermal activity

;

Localisation / Location

INIST-CNRS, Cote INIST : 11143, 35400017007692.0230

Nº notice refdoc (ud4) : 22019811



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