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Titre du document / Document title

Atromentin-Induced Apoptosis in Human Leukemia U937 Cells

Auteur(s) / Author(s)

KIM JIN HEE (1) ; CHOONG HWAN LEE (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, COREE, REPUBLIQUE DE

Résumé / Abstract

In the course of screening for apoptotic substances that induce apoptosis in human leukemia U937 cells, a fungal strain, F000487, which exhibits potent inducible activity, was selected. The active compound was purified from an ethyl acetate extract of the microorganism by Sep-pak C18 column chromatography and HPLC, and was identified as atromentin by spectroscopic methods. This compound induced caspase-3 processing in human leukemia U937 cells. The caspase-3 and poly (ADP-ribose) polymerase (PARP) were induced by atromentin in a dose-dependent manner. Furthermore, DNA fragmentation was also induced by this compound in a dose-dependent manner. These results show that atromentin potently induces apoptosis in U937 cells and that atromentin-induced apoptosis is related to the selective activation of caspases.

Revue / Journal Title

Journal of microbiology and biotechnology    ISSN  1017-7825 

Source / Source

2009, vol. 19, no9, pp. 946-950 [5 page(s) (article)] (28 ref.)

Langue / Language

Anglais

Editeur / Publisher

Korean Society for Applied Microbiology, Seoul, COREE, REPUBLIQUE DE  (1991) (Revue)

Mots-clés anglais / English Keywords

Tumor cell

;

Human

;

Apoptosis

;

Mots-clés français / French Keywords

Cellule tumorale

;

Homme

;

Apoptose

;

Mots-clés espagnols / Spanish Keywords

Célula tumoral

;

Hombre

;

Apoptosis

;

Mots-clés d'auteur / Author Keywords

Apoptosis

;

atromentin

;

U937 cells

;

Localisation / Location

INIST-CNRS, Cote INIST : 26482, 35400017109563.0130

Nº notice refdoc (ud4) : 21945937



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