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Titre du document / Document title

Growth Factors, Inflammatory Cytokines and Postnatal Bone Strength in Preterm Infants

Auteur(s) / Author(s)

ELIAKIM Alon ; NEMET Dan ; AHMAD Irfan ; ZALDIVAR Frank ; KOPPEL Robin ; GROCHOW Donna ; WAFFARN Feizal ; COOPER Dan M. ;

Résumé / Abstract

Aim: To assess the relationships between growth factors, inflammatory cytokines and postnatal bone development in preterm infants. Methods: Fifty premature infants (24-32 weeks gestational age, mean birth weight: 1,024 ± 50 g) participated in the study. Bone strength was determined weekly by quantitative ultrasound measurements of bone speed of sound (SOS). Blood serum measurements of growth factors included circulating IGF-I and GH binding protein. Measurements of circulating cytokines included the pro-inflammatory mediator interleukin (IL)-6, and the anti-inflammatory mediator IL-1 receptor antagonist. Samples were collected when the preterm infants were stabilized and prior to discharge. Results: Despite a significant increase in body weight (from 1,024 ± 50 to 2,420 ± 59 g, p <0.001) and body length (from 35.4 ± 0.6 to 44.6 ± 0.4 cm, p <0.001) there was a significant decrease in bone SOS during the follow-up period. There was a significant increase in growth factors and a decrease in inflammatory cytokines during the follow-up. Participants were divided into preterm infants who increased bone SOS (bone gainers, n = 16, from 2,867 ± 38 to 2,910 ± 41 m/sec), or decreased bone SOS (bone losers, n = 34, from 2,967 ± 33 to 2,818 ± 28 m/sec) during follow-up. Baseline bone SOS was significantly lower in the bone gainers. Baseline circulating growth factors were higher and inflammatory cytokines lower in the bone gainers; however, only the difference in IL-6 reached statistical significance (6.4 ± 1.6 versus 10.5 ± 1.2 pg/ml, in bone gainers and losers, respectively; p <0.05). Conclusions: Preterm infants with lower bone SOS at birth tend to 'catch-up' during early postnatal weeks. Increases in bone strength in preterm infants were associated with reduced inflammatory state as suggested by lower levels of circulating IL-6.

Revue / Journal Title

Journal of pediatric endocrinology & metabolism    ISSN  0334-018X 

Source / Source

2009, vol. 22, no8, pp. 733-740 [8 page(s) (article)]

Langue / Language


Editeur / Publisher

Freund, Tel Aviv, ISRAEL  (1985) (Revue)

Mots-clés d'auteur / Author Keywords



speed of sound






premature infants


Localisation / Location

INIST-CNRS, Cote INIST : 20997, 35400017110298.0070

Nº notice refdoc (ud4) : 21939759

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