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Titre du document / Document title

Treatment of hepatic metastasis of the Colon26 adenocarcinoma with an α-galactosylceramide, KRN7000

Auteur(s) / Author(s)

NAKAGAWA R. (1) ; MOTOKI K. (1) ; UENO H. (1) ; IIJIMA R. (1) ; NAKAMURA H. (1) ; KOBAYASHI E. (1) ; SHIMOSAKA A. (1) ; KOEZUKA Y. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma 370-12, JAPON

Résumé / Abstract

Colorectal liver metastasis is clinically a major problem. We examined the antitumor activity of KRN7000, an α-galactosylceramide, on mice with liver metastases of adenocarcinoma Colon26 cells. KRN7000 treatment, heginning I day after tumor inoculation (day 1), significantly inhibited tumor growth in the liver, and its potency was equal to that of interleukin 12. KRN70000 treatment from day 3 caused regression of estahlished Colon26 nodules. KRN7000 administration resulted in a high percentage of cured mice that acquired tumor-specific immunity. In addition, it appeared that highly activated, liver-associated natural killer cells made the major contribution to the killing of Colon26 cells in the liver. These results suggest that KRN7000 may he useful for the treatment of colorectal liver metastasis.

Revue / Journal Title

Cancer research    ISSN  0008-5472   CODEN CNREA8 

Source / Source

1998, vol. 58, no6, pp. 1202-1207 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Association for Cancer Research, Philadelphia, PA, ETATS-UNIS  (1941) (Revue)

Mots-clés anglais / English Keywords

Antimetastatic agent

;

Treatment

;

Interleukin 12

;

Adenocarcinoma

;

Liver

;

Malignant tumor

;

Colon

;

Rectum

;

Metastasis

;

Animal

;

Mouse

;

Immunotherapy

;

Tumoral tissue

;

Rodentia

;

Mammalia

;

Vertebrata

;

Digestive diseases

;

Intestinal disease

;

Colonic disease

;

Rectal disease

;

Mots-clés français / French Keywords

Antimétastatique

;

Traitement

;

Interleukine 12

;

Adénocarcinome

;

Foie

;

Tumeur maligne

;

Côlon

;

Rectum

;

Métastase

;

Animal

;

Souris

;

Immunothérapie

;

Tissu tumoral

;

KRN 7000

;

α-Galactosylcéramide

;

Rodentia

;

Mammalia

;

Vertebrata

;

Appareil digestif pathologie

;

Intestin pathologie

;

Côlon pathologie

;

Rectum pathologie

;

Mots-clés espagnols / Spanish Keywords

Antimetastásico

;

Tratamiento

;

Interleuquina 12

;

Adenocarcinoma

;

Hígado

;

Tumor maligno

;

Colón

;

Recto

;

Metástasis

;

Animal

;

Ratón

;

Inmunoterapia

;

Tejido tumoral

;

Rodentia

;

Mammalia

;

Vertebrata

;

Aparato digestivo patología

;

Intestino patología

;

Colón patología

;

Recto patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 5088, 35400007508089.0230

Nº notice refdoc (ud4) : 2190240



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