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Titre du document / Document title

Pre- and post-treatment serum levels of cytokines IL-1β, IL-6, and IL-1 receptor antagonist in celiac disease. Are they related to the associated osteopenia?

Auteur(s) / Author(s)

FORNARI M. C. ; PEDREIRA S. ; NIVELONI S. ; GONZALEZ D. ; DIEZ R. A. ; VAZQUEZ H. ; MAZURE R. ; SUGAI E. ; SMECUOL E. ; BOERR L. ; MAURINO E. ; BAI J. C. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Sección Intestino Delgado, Servicio de Clínica, Departamento de Medicina, Hospital de Gastroenterología Dr Carlos Bonorino Udaondo, ARGENTINE
Universidad del Salvador, Laboratorio de Inmunofarmacología, Facultad de Medicina (UBA), ARGENTINE
Centro de Osteopatías Médicas y Reumatología, Hospital de Clínicas (UBA), Buenos Aires, ARGENTINE

Résumé / Abstract

Objective: Decreased bone mineral density is a common finding in untreated celiac disease patients. However, the precise pathophysiology of osteopenia remains incompletely understood. Pathological features of gluten sensitivity are associated with local release of proinflammatory and antiinflammatory cytokines. We investigated the serum levels of IL-lβ, IL-6, and IL-1 receptor antagonist in celiac patients and correlated them with bone density measurements. Methods: We assessed serum samples of 16 female patients at the time of diagnosis (on an unrestricted diet) and after a mean time of 37 months on a gluten-free diet. At the same time, bone mineral density in the lumbar spine and total skeleton was determined by DEXA. Results: Untreated patients had high serum levels of IL-lβ and IL-6 and normal IL-1-RA. Treatment produced a decrease in median IL-lβ levels (p = NS) and a significant diminution of IL-6 (p < 0.05). On the contrary, IL-1-RA increased significantly after treatment (p < 0.05). Baseline lumbar spine Z-score and IL-6 levels exhibited a significant inverse correlation (r = -0.61; p < 0.01). Patients with more severe baseline osteopenia (< -2 Z-scores) had a significantly lower IL-1-RA than those with less bone compromise (> -2 Z-scores). Conclusions: Our data demonstrate that the inflammatory process observed in active celiac disease is associated with high serum levels of IL-lβ and IL-6 and normal levels of IL-1-RA. Treatment significantly reduces both proinflammatory cytokines and significantly increases the antiinflammatory one. We also suggest that these cytokines might have a role in the osteopenia associated with celiac disease.

Revue / Journal Title

The American journal of gastroenterology    ISSN  0002-9270 

Source / Source

1998, vol. 93, no3, pp. 413-418 (28 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing Group, Basingstoke, ROYAUME-UNI  (1954) (Revue)

Mots-clés anglais / English Keywords

Coeliac disease

;

Evaluation

;

After effect

;

Interleukin 1β

;

Interleukin 6

;

Association

;

Osteopenia

;

Treatment

;

Effectiveness factor

;

Human

;

Digestive diseases

;

Intestinal disease

;

Intestinal malabsorption

;

Immunopathology

;

Cytokine

;

Diseases of the osteoarticular system

;

Bone disease

;

Mots-clés français / French Keywords

Coeliaque maladie

;

Evaluation

;

Effet consécutif

;

Interleukine 1β

;

Interleukine 6

;

Association

;

Ostéopénie

;

Traitement

;

Facteur efficacité

;

Homme

;

Appareil digestif pathologie

;

Intestin pathologie

;

Malabsorption intestinale

;

Immunopathologie

;

Cytokine

;

Système ostéoarticulaire pathologie

;

Ostéopathie

;

Mots-clés espagnols / Spanish Keywords

Enfermedad celíaca

;

Evaluación

;

Efecto posterior

;

Interleuquina 1β

;

Interleuquina 6

;

Asociación

;

Osteopenia

;

Tratamiento

;

Factor de eficacia

;

Hombre

;

Aparato digestivo patología

;

Intestino patología

;

Malabsorción intestinal

;

Inmunopatología

;

Citoquina

;

Sistema osteoarticular patología

;

Osteopatía

;

Localisation / Location

INIST-CNRS, Cote INIST : 11062, 35400007934681.0260

Nº notice refdoc (ud4) : 2182309



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