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Titre du document / Document title

Essential monoclonal gammopathy with an IgM paraprotein that is a cryoglobulin with cold agglutinin and EDTA-dependent platelet antibody properties

Auteur(s) / Author(s)

PUJOL M. (1) ; RIBERA J. M. (1) ; JIMENEZ C. (1) ; RIBERA A. (2) ; ABAD E. (3) ; FELIU E. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Servicio de Hematologia y Hemoterapia del Hospital Universitario Germans Trias y Pujol, Badalona, ESPAGNE
(2) Banco de Sangre del ICS, Barcelona, ESPAGNE
(3) Servicio de Análisis Clinicos del Hospital Universitario Germans Trias y Pujol, Badalona, ESPAGNE

Résumé / Abstract

A patient with apparent anaemia and thrombocytopenia caused by a monoclonal paraprotein is described. The patient's serum contained a monoclonal IgM kappa, a cryoglobulin and a cold agglutinin. The cryoglobulin, similar to the serum paraprotein, was a monoclonal IgM kappa. Serum was studied to determine the relationship of the cryoglobulin with the cold agglutinin. The cryoglobulin and cold agglutinin were found to be the same paraprotein. Moreover, with absorption and elution techniques the reactivity of the autoantibody with both erythrocytes and platelets was demonstrated. Reports of cryoprecipitable cold agglutinins are rare and therefore this case is exceptional given that the IgM kappa paraprotein was found to be a cold agglutinin which was also reactive with platelets.

Revue / Journal Title

British journal of haematology    ISSN  0007-1048   CODEN BJHEAL 

Source / Source

1998, vol. 100, no3, pp. 603-604 (5 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1955) (Revue)

Mots-clés anglais / English Keywords

Monoclonal immunoglobulinemia

;

Case study

;

Female

;

Elderly

;

IgM

;

Cold agglutinin

;

Kappa light peptide chain

;

Autoantibody

;

Platelet

;

Thrombocytopenia

;

Human

;

Hemopathy

;

Mots-clés français / French Keywords

Immunoglobulinémie monoclonale

;

Etude cas

;

Femelle

;

Vieillard

;

IgM

;

Agglutinine froide

;

Chaîne peptidique légère κ

;

Autoanticorps

;

Thrombocyte

;

Thrombopénie

;

Paraprotéine

;

Homme

;

Hémopathie

;

Mots-clés espagnols / Spanish Keywords

Inmunoglobulinemia monoclonal

;

Estudio caso

;

Hembra

;

Anciano

;

IgM

;

Aglutinina fría

;

Cadena peptídica ligera κ

;

Autoanticuerpo

;

Trombocito

;

Trombopenia

;

Hombre

;

Hemopatía

;

Localisation / Location

INIST-CNRS, Cote INIST : 7597, 35400007871602.0260

Nº notice refdoc (ud4) : 2164738



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