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Titre du document / Document title

The Notch Ligands DII4 and Jagged1 Have Opposing Effects on Angiogenesis

Auteur(s) / Author(s)

BENEDITO Rui ; ROCA Cristina ; SÖRENSEN Inga ; ADAMS Susanne ; GOSSLER Achim ; FRUTTIGER Marcus ; ADAMS Ralf H. ;

Résumé / Abstract

The Notch pathway is a highly conserved signaling system that controls a diversity of growth, differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is activated by binding of the Notch receptor to its ligand Delta-like 4 (DII4). Here, we show that the Notch ligand Jagged1 is a potent proangiogenic regulator in mice that antagonizes DII4-Notch signaling in cells expressing Fringe family glycosyltransferases. Upon glycosylation of Notch, DII4-Notch signaling is enhanced, whereas Jagged1 has weak signaling capacity and competes with DII4. Our findings establish that the equilibrium between two Notch ligands with distinct spatial expression patterns and opposing functional roles regulates angiogenesis, a mechanism that might also apply to other Notch-controlled biological processes.

Revue / Journal Title

Cell    ISSN  0092-8674   CODEN CELLB5 

Source / Source

2009, vol. 137, no6, pp. 1123-1134 [12 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Cell Press, Cambridge, MA, ETATS-UNIS  (1974) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 16529, 35400018860016.0180

Nº notice refdoc (ud4) : 21618083



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