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Titre du document / Document title

Selenium and Inflammation: Underlying Anti-inflammatory Mechanisms

Auteur(s) / Author(s)

DUNTAS L. H. ;

Résumé / Abstract

The essential trace element selenium (Se), in the form of selenoproteins, plays a pivotal role in the antioxidant defense system of the cell. There is evidence that Se may confer benefits in patients with inflammatory disease and even infectious diseases like HIV. Furthermore, in patients with severe sepsis, characterized by an increase in reactive oxygen species and low endogenous anti-oxidative capacity, as well as in patients with systemic inflammatory response syndrome, Se supplementation may reduce mortality and improve the clinical outcome, respectively. The nuclear factor kappa-B (NF-κB) signaling pathway has been associated with enhanced inflammatory response and its activation has been significantly correlated with interleukin-6 and TNF-α production. Selenium may inhibit the activation of NF-κB by modulating selenoprotein genes expression. Moreover, Se supplementation in chronic inflammation restores the depleted hepatic and serum Se levels by increasing selenoprotein biosynthesis leading to suppressed CRP production thereby attenuating the inflammatory process. Se increases shedding of L-selectin from monocytes while decreasing soluble L-selectin, which has been reported to be associated with high mortality in patients with sepsis. These mechanisms are likely to contribute to the modulatory effects of an increased Se status on the inflammatory response. This review evaluates some apparently key mechanisms of the anti-inflammatory action of selenium and advocates Se supplementation as a modulator of inflammatory response in infectious and autoimmune disease. Prospective, randomized, controlled studies must be performed to provide a greater degree of certainty.

Revue / Journal Title

Hormone and metabolic research    ISSN  0018-5043   CODEN HMMRA2 

Source / Source

2009, vol. 41, no6, pp. 443-447 [5 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1969) (Revue)

Mots-clés d'auteur / Author Keywords

selenium

;

inflammation

;

selenoproteins

;

NF-κB

;

CRP

;

Localisation / Location

INIST-CNRS, Cote INIST : 14356, 35400018851163.0060

Nº notice refdoc (ud4) : 21535112



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