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Titre du document / Document title

Clinical manifestations and survival of hepatocellular carcinoma patients with peritoneal metastasis

Auteur(s) / Author(s)

LIN Chien-Chu (1 3) ; LIANG Hsiao-Ping (2) ; LEE Hsuan-Shu (3) ; HUANG Guan-Tarn (3) ; YANG Pei-Ming (3) ; HO Ming-Chih (4) ; LEE Po-Huang (4) ; TSANG Yuk-Ming (5) ; CHEN Ding-Shinn (3 6) ; SHEU Jin-Chuan (3) ; CHEN Chien-Hung (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Internal Medicine, Far Eastern Memorial Hospital, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TAIWAN, PROVINCE DE CHINE
(2) Bobson Obs-Gyn Clinic, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TAIWAN, PROVINCE DE CHINE
(3) Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TAIWAN, PROVINCE DE CHINE
(4) Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TAIWAN, PROVINCE DE CHINE
(5) Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TAIWAN, PROVINCE DE CHINE
(6) Hepatitis Research Center, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TAIWAN, PROVINCE DE CHINE

Résumé / Abstract

Background and Aim: Peritoneal metastasis is an uncommon manifestation of hepatocellular carcinoma (HCC). The aim of the present paper was to investigate the characteristics and survival of HCC patients with peritoneal metastases. Methods: From January 1985 to December 2004, we retrospectively reviewed the records of 53 Taiwanese HCC patients with peritoneal metastases. Results: Peritoneal metastases were detected at the time of HCC diagnosis (synchronously) in 10 patients and after the initial therapy for the primary tumors (metachronously) in 43 patients. The mean time for development of the metachronous peritoneal metastases was similar whether the primary cancer was treated with surgery (24 months) or transarterial chemoembolization (22.2 months). The single patient whose primary cancer was treated with supportive care alone developed peritoneal metastasis only 7.5 months after detection of the primary cancer. Surgical resection of the peritoneal metastases was possible in two-thirds of the 43 metachronous patients. The median survival for those who received surgery for these metastases was 12.5 months vs. 2.1 months for those without surgery (P = 0.0013). However, there was no difference in survival if patients were stratified to Child-Pugh grade. Conclusions: Peritoneal metastases of HCC are rare and can occur synchronously or metachronously. Though increased long-term survival was found in patients who had surgical removal of peritoneal metastases, the main determinant of better survival is Child-Pugh grade.

Revue / Journal Title

Journal of gastroenterology and hepatology    ISSN  0815-9319 

Source / Source

2009, vol. 24, no5, pp. 815-820 [6 page(s) (article)] (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Blackwell, Richmond, AUSTRALIE  (1986) (Revue)

Mots-clés anglais / English Keywords

Abdominal disease

;

Cancer

;

Malignant tumor

;

Hepatic disease

;

Digestive diseases

;

Prognosis

;

Gastroenterology

;

Treatment

;

Peritoneum

;

Human

;

Survival

;

Symptomatology

;

Peritoneal metastasis

;

Hepatocellular carcinoma

;

Mots-clés français / French Keywords

Pathologie de l'abdomen

;

Cancer

;

Tumeur maligne

;

Pathologie du foie

;

Pathologie de l'appareil digestif

;

Pronostic

;

Gastroentérologie

;

Traitement

;

Péritoine

;

Homme

;

Survie

;

Symptomatologie

;

Métastase péritonéale

;

Carcinome hépatocellulaire

;

Mots-clés espagnols / Spanish Keywords

Abdomen patología

;

Cáncer

;

Tumor maligno

;

Hígado patología

;

Aparato digestivo patología

;

Pronóstico

;

Gastroenterología

;

Tratamiento

;

Peritoneo

;

Hombre

;

Sobrevivencia

;

Sintomatología

;

Metástasis peritoneal

;

Carcinoma hepatocelular

;

Mots-clés d'auteur / Author Keywords

hepatocellular carcinoma

;

metastasis, peritoneum

;

treatment

;

Localisation / Location

INIST-CNRS, Cote INIST : 21223, 35400018612482.0200

Nº notice refdoc (ud4) : 21473735



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