Titre du document / Document title

Longterm prospective study of methotrexate in rheumatoid arthritis : Conclusion after 132 months of therapy

Auteur(s) / Author(s)

WEINBLATT M. E. ⁽¹⁾ ; MAIER A. L. ⁽¹⁾ ; FRASER P. A. ⁽¹⁾ ; COBLYN J. S. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Rheumatology and Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, ETATS-UNIS

Résumé / Abstract

Objective. To conclude observations of efficacy of longterm methotrexate (MTX) treatment of rheumatoid arthritis (RA). Methods. Twenty-six patients with RA entered a prospective study of MTX in 1983. The study was completed after 132 months of therapy. Results. Significant improvement (p < 0.001) was noted in the number of painful joints, swollen joints, and physician and patient global assessments. There was 50% improvement in the joint pain index and joint swelling index in > 65% of the patients. A significant reduction in prednisone dose was achieved. Sixteen patients withdrew from the study. Toxicity led to 3 drug related withdrawals of study patients (alopecia 1; pneumonitis 2). At 132 months, 10 patients (38%) had completed the study; 3 patients (11%) discontinued due to MTX toxicity. Conclusion. MTX was an effective treatment for RA in this 132 month prospective study.

Revue / Journal Title

Journal of rheumatology   ISSN 0315-162X   CODEN JRHUA9 

Source / Source

1998, vol. 25, n^o2, pp. 238-242 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Journal of Rheumatology Publishing, Toronto, ON, CANADA  (1974) (Revue)

Mots-clés anglais / English Keywords

Rheumatoid arthritis ; Human ; Treatment ; Methotrexate ; Chemotherapy ; Follow up study ; Treatment efficiency ; Long term ; Chronic ; Antifolate ; Immunosuppressive agent ; Diseases of the osteoarticular system ; Inflammatory joint disease ; Immunopathology ; Autoimmune disease ;

Mots-clés français / French Keywords

Polyarthrite rhumatoïde ; Homme ; Traitement ; Méthotrexate ; Chimiothérapie ; Etude longitudinale ; Efficacité traitement ; Long terme ; Chronique ; Antifolate ; Immunodépresseur ; Système ostéoarticulaire pathologie ; Rhumatisme inflammatoire ; Immunopathologie ; Maladie autoimmune ;

Mots-clés espagnols / Spanish Keywords

Poliartritis reumatoidea ; Hombre ; Tratamiento ; Metotrexato ; Quimioterapia ; Estudio longitudinal ; Eficacia tratamiento ; Largo plazo ; Crónico ; Antifolato ; Inmunodepresor ; Sistema osteoarticular patología ; Reumatismo inflamatorio ; Inmunopatología ; Enfermedad autoinmune ;

Localisation / Location

INIST-CNRS, Cote INIST : 16024, 35400007831325.0100